The Wayro route from Zamora to Puerto López is 402 miles (647 km), about 9 h 26 min of driving without stops.
- Level 4: Do Not Travel in Ecuador: Duran, in Guayas province.
- Level 4: Do Not Travel in Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3).
- Level 3: Reconsider Travel in Ecuador: El Oro province, outside Huaquillas and Arenillas.
- Level 3: Reconsider Travel in Ecuador: Sucumbios, Manabi, Santa Elena, and Santo Domingo provinces.
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Ecuador. Advisory issued: Ecuador August 18, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Ecuador: “Slow-moving buses and trucks frequently stop in the middle of the road unexpectedly.”
| Total distance | 402 mi (647 km) |
|---|---|
| Drive time without stops | 9 h 26 min |
| Main roads, in order | E50 → E35 → E25 → E40 → E48 → E482 → E483 → E15 |
| Provinces on the route | Zamora Chinchipe, Loja, El Oro, Azuay, Guayas, Manabi |
| Fuel estimate (car at 25 mpg) | about 16.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 4 |
On the road from Zamora to Puerto López
E50 (113 mi) and E25 (105 mi) carry about 54% of the 402 miles. It runs through 6 provinces: Zamora Chinchipe, Loja, El Oro, Azuay, Guayas, Manabi. Of the 4 stops listed below, 3 are within a mile of the road.
Which roads connect Zamora and Puerto López
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–1 | 1 | Zamora Chinchipe |
| E50 | 1–36 | 35 | Zamora Chinchipe, Loja |
| connecting roads | 36–39 | 3 | Loja |
| local roads | 39–48 | 9 | Loja |
| connecting roads | 48–55 | 7 | Loja |
| E35 | 55–79 | 24 | Loja |
| E50 | 79–157 | 78 | Loja, El Oro |
| E25 | 157–262 | 105 | El Oro, Azuay, Guayas |
| E40 | 262–280 | 18 | Guayas |
| local roads | 280–290 | 10 | Guayas |
| E48 | 290–304 | 14 | Guayas |
| E482 | 304–366 | 62 | Guayas, Manabi |
| E483 | 366–382 | 16 | Manabi |
| E15 | 382–402 | 20 | Manabi |
- Mile 27 of this route: Zamora Chinchipe → Loja (province line)
- Mile 120 of this route: Loja → El Oro (province line)
- Mile 195 of this route: El Oro → Azuay (province line)
- Mile 200 of this route: Azuay → Guayas (province line)
- Mile 334 of this route: Guayas → Manabi (province line)
What to see on the way from Zamora to Puerto López
- Right off the route (under 1 mile): Cathedral of Loja-Parroquia El Sagrario (mile 35), Parque Histórico de Guayaquil (mile 280), Jardín Botánico de Guayaquil (mile 288)
- Nature and outdoors: Parque Histórico de Guayaquil (mile 280), Jardín Botánico de Guayaquil (mile 288)
- Museums and history: Cathedral of Loja-Parroquia El Sagrario (mile 35), Museo Antropologico y de Arte Contemporaneo (mile 280)
Cathedral of Loja-Parroquia El Sagrario
Loja Cathedral (Catedral de Loja) stands on the Parque Central in the center of Loja, about 70 km from the El Cisne sanctuary, and serves as the seat of the Diocese of Loja.
Museo Antropologico y de Arte Contemporaneo
Known as MAAC, the Museo Antropologico y de Arte Contemporaneo in Guayaquil, Ecuador, celebrates Ecuadorian, Latin American and pre-Columbian art and culture on the Malecón 2000 riverwalk.
Parque Histórico de Guayaquil
Parque Histórico de Guayaquil combines a wildlife area showing local plants and animals with old city houses that were taken down from their original sites and rebuilt here.
Jardín Botánico de Guayaquil
Living plant collections grown for conservation, research and education fill the Jardín Botánico de Guayaquil, a 5-hectare botanical garden in Guayaquil, Ecuador.
Arriving in Puerto López
Machalilla National Park
Established in 1979, Machalilla National Park sits along the Pacific coast of Ecuador's Manabí Province, near Puerto López and the fishing village of Machalilla.
More drives to Puerto López
- Riobamba to Puerto López
- Baños to Puerto López
- Quito to Puerto López
- Puyo to Puerto López
- Otavalo to Puerto López
- Ibarra to Puerto López
From Zamora to other places in Ecuador
- Zamora to Agua Blanca
- Zamora to Puerto Cayo
- Zamora to Canoa
- Zamora to Mindo
- Zamora to Máncora, Peru
- Zamora to Zorritos, Peru
Frequently asked questions
How long is the drive from Zamora to Puerto López?
About 9 h 26 min of driving without stops, over 402 miles.
What is the driving distance from Zamora to Puerto López?
About 402 miles (647 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Zamora to Puerto López?
The U.S. State Department rates Ecuador Level 2: Exercise Increased Caution. Parts of this route are in or near areas rated Level 4: Do Not Travel (Ecuador: Duran, in Guayas province; Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3)). Read the full advisory before you go.
What roads does the drive from Zamora to Puerto López use?
In order: E50, E35, E25, E40, E48, E482, E483 and E15. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Zamora to Puerto López?
Closest to the road: Cathedral of Loja-Parroquia El Sagrario (cathedral, mile 35, 0.9 mi from the route); Parque Histórico de Guayaquil (park, mile 280, 0.6 mi from the route); Jardín Botánico de Guayaquil (botanical garden, mile 288, 0.8 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.