The Wayro route from Sincelejo to Cartago, Colombia is 448 miles (721 km), about 10 h 18 min of driving without stops.
- Level 4: Do Not Travel in Colombia: Valle del Cauca (excluding Cali).
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Colombia. Advisory issued: Colombia March 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Colombia: “Travel only during daylight hours.”
| Distance by road | 448 mi (721 km) |
|---|---|
| Time at the wheel, no stops | 10 h 18 min |
| Main roads, in order | 25BAN |
| Departments on the route | Sucre, Córdoba, Antioquia, Caldas, Risaralda, Valle del Cauca |
| Fuel estimate (car at 25 mpg) | about 17.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 6 |
How the Sincelejo to Cartago drive plays out
25BAN (42 mi) carries about 9% of the 448 miles. It runs through 6 departments: Sucre, Córdoba, Antioquia, Caldas, Risaralda, Valle del Cauca. Of the 6 stops listed below, 6 are within a mile of the road.
The route from Sincelejo to Cartago, road by road
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–298 | 298 | Sucre, Córdoba, Antioquia |
| connecting roads | 298–299 | 1 | Antioquia |
| local roads | 299–304 | 5 | Antioquia |
| connecting roads | 304–306 | 2 | Antioquia |
| local roads | 306–313 | 7 | Antioquia |
| 25BAN | 313–355 | 42 | Antioquia |
| local roads | 355–448 | 93 | Caldas, Risaralda, Valle del Cauca |
- Mile 16 of this route: Sucre → Córdoba (department line)
- Mile 111 of this route: Córdoba → Antioquia (department line)
- Mile 355 of this route: Antioquia → Caldas (department line)
- Mile 391 of this route: Caldas → Risaralda (department line)
- Mile 394 of this route: Risaralda → Caldas (department line)
- Mile 431 of this route: Caldas → Risaralda (department line)
- Mile 446 of this route: Risaralda → Valle del Cauca (department line)
What to see on the way from Sincelejo to Cartago
- Right off the route (under 1 mile): Basilica of Our Lady of Mercy (mile 214), Our Lady of the Rosary of Chiquinquirá Cathedral (mile 244), Our Lady of the Rosary Cathedral, Girardota (mile 276), Parque Explora (mile 289), Medellín Museum of Modern Art (mile 293), Basílica Menor Nuestra Señora del Rosario de Chiquinquirá, La Estrella (mile 300)
- Museums and history: Basilica of Our Lady of Mercy (mile 214), Our Lady of the Rosary of Chiquinquirá Cathedral (mile 244), Our Lady of the Rosary Cathedral, Girardota (mile 276), Parque Explora (mile 289), Medellín Museum of Modern Art (mile 293), Basílica Menor Nuestra Señora del Rosario de Chiquinquirá, La Estrella (mile 300)
- With kids: Parque Explora (mile 289)
Basilica of Our Lady of Mercy
A minor basilica in Yarumal, the Basilica of Our Lady of Mercy belongs to the Diocese of Santa Rosa de Osos and serves as the parish church.
Our Lady of the Rosary of Chiquinquirá Cathedral
Facing the south side of Bolívar Park in Santa Rosa de Osos, Colombia, this cathedral is dedicated to the Virgin Mary as Our Lady of the Rosary of Chiquinquirá.
Our Lady of the Rosary Cathedral, Girardota
Girardota Cathedral is a Neo-Romanesque church of exposed brick, designed by French architect Charles Émile Carré and built over 32 years.
Parque Explora
Parque Explora in Medellín is an interactive science museum that also houses the Explora Aquarium, described as South America's largest freshwater aquarium.
Medellín Museum of Modern Art
Medellín's Museum of Modern Art, founded in 1978, is a modern art museum in the Colombian city of Medellín.
Basílica Menor Nuestra Señora del Rosario de Chiquinquirá, La Estrella
Part of the Archdiocese of Medellín, this Catholic minor basilica dedicated to Our Lady of the Rosary of Chiquinquirá stands in the municipality of La Estrella, Antioquia.
In Cartago itself
Our Lady of Mount Carmel Cathedral, Valle del Cauca
Two blocks from Bolívar Park in Cartago, Valle del Cauca, the Cathedral of Our Lady of Mount Carmel stands out for a bell tower set twenty meters apart from the church.
Casa del Virrey
A colonial-era building in Cartago, Casa del Virrey takes its name from the popular tradition that it was built to receive Viceroy José Manuel de Ezpeleta.
More drives to Cartago
- Ibagué to Cartago, Colombia
- Bogotá to Cartago, Colombia
- Villavicencio to Cartago, Colombia
- Tunja to Cartago, Colombia
- Yopal to Cartago, Colombia
- Pitalito to Cartago, Colombia
From Sincelejo to other places in Colombia
- Sincelejo to Quibdó
- Sincelejo to Zipaquirá
- Sincelejo to Tuluá
- Sincelejo to Palomino
- Sincelejo to Guachaca
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Sincelejo to Cartago, Colombia?
About 10 h 18 min of driving without stops, over 448 miles.
How far is Cartago, Colombia from Sincelejo by car?
About 448 miles (721 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Sincelejo to Cartago, Colombia?
The U.S. State Department rates Colombia Level 3: Reconsider Travel. Parts of this route are in or near areas rated Level 4: Do Not Travel (Colombia: Valle del Cauca (excluding Cali)). Read the full advisory before you go.
Where can you stop on the way from Sincelejo to Cartago?
Closest to the road: Our Lady of the Rosary of Chiquinquirá Cathedral (cathedral, mile 244, 0.4 mi from the route); Parque Explora (science museum, mile 289, 0.4 mi from the route); Medellín Museum of Modern Art (art museum, mile 293, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.