Plan on about 8 h 42 min of driving for the 383-mile (617 km) trip from Santos to Nova Serrana, before any stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Flooding makes some roads through the Amazon impassable for much of the year.”
| Distance by road | 383 mi (617 km) |
|---|---|
| Driving time, no stops | 8 h 42 min |
| Main roads, in order | SP-150 → SP-010 → SP-008 → BR-381 → BR-494 → BR-262 |
| States on the route | São Paulo, Minas Gerais |
| Fuel estimate (car at 25 mpg) | about 15.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
How the Santos to Nova Serrana drive plays out
SP-008 (156 mi) and BR-381 (84 mi) carry about 63% of the 383 miles. It runs through 2 states: São Paulo, Minas Gerais. Of the 9 stops listed below, 2 are within a mile of the road.
The route from Santos to Nova Serrana, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | São Paulo |
| SP-150 | 4–40 | 36 | São Paulo |
| connecting roads | 40–41 | 1 | São Paulo |
| local roads | 41–47 | 6 | São Paulo |
| connecting roads | 47–50 | 3 | São Paulo |
| SP-010 | 50–70 | 20 | São Paulo |
| SP-008 | 70–226 | 156 | São Paulo, Minas Gerais |
| BR-381 | 226–310 | 84 | Minas Gerais |
| BR-494 | 310–378 | 68 | Minas Gerais |
| BR-262 | 378–383 | 5 | Minas Gerais |
- Mile 107 of this route: São Paulo → Minas Gerais (state line)
Where to stop on the way to Nova Serrana
- Right off the route (under 1 mile): Nelson Rodrigues Theatre (mile 53), Cantareira State Park (mile 56)
- Nature and outdoors: Albert Löfgren State Park (mile 52), Cantareira State Park (mile 56)
- Museums and history: Sabina Escola Parque do Conhecimento (mile 33), Museu de Santo André (mile 34), Historical Museum of São Caetano do Sul (mile 40), CAIXA Cultural São Paulo (mile 43), Pinacoteca do Estado de São Paulo (mile 47), Holy Spirit Cathedral, Divinópolis (mile 358)
- With kids: Sabina Escola Parque do Conhecimento (mile 33)
Sabina Escola Parque do Conhecimento
Sabina Escola Parque do Conhecimento is a science museum in Santo André, in Greater São Paulo, and one of the area's planetarium venues.
Museu de Santo André
Museu de Santo André Dr. Octaviano Armando Gaiarsa is one of the main museums in the city of Santo André, São Paulo.
Historical Museum of São Caetano do Sul
Run by the Fundação Pró-Memória, the Historical Museum of São Caetano do Sul (Museu Histórico Municipal) is the city's municipal history museum, set in São Caetano do Sul.
CAIXA Cultural São Paulo
CAIXA Cultural São Paulo is a museum and community center, one of the CAIXA Cultural network's units, maintained by Caixa Econômica Federal.
Pinacoteca do Estado de São Paulo
Founded by the state government in 1905, the Pinacoteca do Estado de São Paulo shows Brazilian art from the 19th century to today across three buildings: Pinacoteca Luz, Pinacoteca Estação and Pinacoteca Contemporânea.
Albert Löfgren State Park
Better known as the São Paulo Forest Gardens, Albert Löfgren State Park is a state-run park in the state of São Paulo, Brazil.
Nelson Rodrigues Theatre
Built on the former headquarters of the farm that gave rise to the Vila Galvão neighborhood, the Nelson Rodrigues Theatre in Guarulhos was designed by architect Ramos de Azevedo.
Cantareira State Park
In the Serra da Cantareira range, Cantareira State Park protects a stretch of Atlantic Forest north of the city of São Paulo.
Holy Spirit Cathedral, Divinópolis
The Holy Spirit Cathedral in Divinópolis, Minas Gerais, is the Roman Catholic church that serves as seat of the Diocese of Divinópolis.
More drives to Nova Serrana
- Itabira to Nova Serrana
- Barbacena to Nova Serrana
- Poços de Caldas to Nova Serrana
- Governador Valadares to Nova Serrana
- Resende to Nova Serrana
- Pindamonhangaba to Nova Serrana
From Santos to other places in Brazil
- Santos to Itanhaém
- Santos to Bragança Paulista
- Santos to Itu
- Santos to Limeira
- Santos to Mogi Guaçu
- Santos to Botucatu
Frequently asked questions
How long is the drive from Santos to Nova Serrana?
About 8 h 42 min of driving without stops, over 383 miles.
What is the driving distance from Santos to Nova Serrana?
About 383 miles (617 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Santos to Nova Serrana drive?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Santos to Nova Serrana?
In order: SP-150, SP-010, SP-008, BR-381, BR-494 and BR-262. The road-by-road table above shows the route miles for each one.
What are good stops between Santos and Nova Serrana?
Closest to the road: Historical Museum of São Caetano do Sul (museum, mile 40, 1 mi from the route); Nelson Rodrigues Theatre (theater, mile 53, 0.4 mi from the route); Cantareira State Park (state park, mile 56, 0.8 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.