The Wayro route from Santos to Itapetininga is 150 miles (241 km), about 3 h 10 min of driving without stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Use caution when walking or driving at night.”
| Distance by road | 150 mi (241 km) |
|---|---|
| Time at the wheel, no stops | 3 h 10 min |
| Main roads, in order | SP-160 → SP-015 → SP-280 → SP-075 → SPI 091/270 → SP-270 |
| States on the route | São Paulo |
| Fuel estimate (car at 25 mpg) | about 6.0 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
On the road from Santos to Itapetininga
SP-270 (46 mi) and SP-280 (40 mi) carry about 57% of the 150 miles. Of the 8 stops listed below, 2 are within a mile of the road.
Which roads connect Santos and Itapetininga
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–6 | 6 | São Paulo |
| SP-160 | 6–41 | 35 | São Paulo |
| local roads | 41–47 | 6 | São Paulo |
| SP-015 | 47–53 | 6 | São Paulo |
| SP-280 | 53–93 | 40 | São Paulo |
| connecting roads | 93–94 | 1 | São Paulo |
| SP-075 | 94–98 | 4 | São Paulo |
| SPI 091/270 | 98–103 | 5 | São Paulo |
| SP-270 | 103–149 | 46 | São Paulo |
| local roads | 149–150 | 1 | São Paulo |
Where to stop on the way to Itapetininga
- Right off the route (under 1 mile): Museu de Ciências da Universidade de São Paulo (mile 40), Museu Biológico do Instituto Butantan (mile 50)
- Nature and outdoors: Jardim Botânico Irmãos Villas-Bôas (mile 103)
- Museums and history: Museu de Ciências da Universidade de São Paulo (mile 40), Obelisk of São Paulo (mile 46), Casa de Vidro (mile 47), Museu das Invenções (mile 50), Museu Biológico do Instituto Butantan (mile 50), Museu histórico e pedagógico Brigadeiro Tobias Aguiar (mile 102), Sorocaba Metropolitan Cathedral (mile 107)
Museu de Ciências da Universidade de São Paulo
The University of São Paulo's Science Museum, created in 2005, brings the exact, human and natural sciences, technology and the arts to the public beyond the campus.
Obelisk of São Paulo
Rising in Ibirapuera Park, the Obelisk of São Paulo is a symbol of the 1932 Constitutionalist Revolution.
Casa de Vidro
Architect Lina Bo Bardi designed the Casa de Vidro, built in 1950–1951 in São Paulo's Morumbi area on land that was once part of a tea farm.
Museu das Invenções
Known as Inventolândia, the Museu das Invenções in São Paulo's Perdizes neighborhood opened in 1996 through the National Association of Inventors, aiming to show students how fun science can be.
Museu Biológico do Instituto Butantan
At the Instituto Butantan in São Paulo, the Museu Biológico displays live snakes, lizards, spiders, and scorpions at an institute that became autonomous in 1901 under its first director, Vital Brazil.
Museu histórico e pedagógico Brigadeiro Tobias Aguiar
Sorocaba's Brigadeiro Tobias Aguiar history museum has a permanent exhibit on the tropeiro mule-driver tradition, with paintings, furniture and everyday tropeiro objects.
Jardim Botânico Irmãos Villas-Bôas
Sorocaba's Jardim Botânico Irmãos Villas-Bôas was created to study the region's flora and to promote environmental awareness and leisure in the city.
Sorocaba Metropolitan Cathedral
Home of the Archdiocese of Sorocaba, the Metropolitan Cathedral of Nossa Senhora da Ponte faces Coronel Fernando Prestes square downtown and dates back more than 200 years.
More drives to Itapetininga
- Itu to Itapetininga
- Campinas to Itapetininga
- Jundiaí to Itapetininga
- Limeira to Itapetininga
- São Paulo to Itapetininga
- Bragança Paulista to Itapetininga
From Santos to other places in Brazil
- Santos to Itanhaém
- Santos to Bragança Paulista
- Santos to Itu
- Santos to Limeira
- Santos to Mogi Guaçu
- Santos to Botucatu
Frequently asked questions
How long is the drive from Santos to Itapetininga?
About 3 h 10 min of driving without stops, over 150 miles.
How far is Itapetininga from Santos by car?
About 150 miles (241 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Santos to Itapetininga drive?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Santos to Itapetininga?
In order: SP-160, SP-015, SP-280, SP-075, SPI 091/270 and SP-270. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Santos to Itapetininga?
Closest to the road: Museu de Ciências da Universidade de São Paulo (museum, mile 40, 0.6 mi from the route); Casa de Vidro (museum, mile 47, 2 mi from the route); Museu Biológico do Instituto Butantan (museum, mile 50, 0.7 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.