Plan on about 6 h 9 min of driving for the 311-mile (501 km) trip from Santos to Barretos, before any stops.
- Level 4: Do Not Travel in Brazil: informal housing developments (favelas, vilas, comunidades or conglomerados).
Full advisory: Brazil. Advisory issued: Brazil August 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Brazil: “Flooding makes some roads through the Amazon impassable for much of the year.”
| Distance | 311 mi (501 km) |
|---|---|
| Time at the wheel, no stops | 6 h 9 min |
| Main roads, in order | SP-160 → SP-015 → SP-348 → SPA-102/330 → SP-330 → SP-310 → SP-326 |
| States on the route | São Paulo |
| Fuel estimate (car at 25 mpg) | about 12.4 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
What the drive from Santos to Barretos is like
SP-310 (87 mi) and SP-326 (80 mi) carry about 54% of the 311 miles. Of the 9 stops listed below, 2 are within a mile of the road.
Roads you'll take from Santos to Barretos
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–6 | 6 | São Paulo |
| SP-160 | 6–41 | 35 | São Paulo |
| local roads | 41–47 | 6 | São Paulo |
| SP-015 | 47–55 | 8 | São Paulo |
| connecting roads | 55–56 | 1 | São Paulo |
| SP-348 | 56–106 | 50 | São Paulo |
| SPA-102/330 | 106–111 | 5 | São Paulo |
| SP-330 | 111–142 | 31 | São Paulo |
| SP-310 | 142–229 | 87 | São Paulo |
| SP-326 | 229–309 | 80 | São Paulo |
| local roads | 309–311 | 2 | São Paulo |
What to see on the way from Santos to Barretos
- Right off the route (under 1 mile): São Paulo Zoo (mile 40), Parque Estadual da Assessoria de Referência Agrária (ARA) (mile 98)
- Nature and outdoors: Parque Estadual da Assessoria de Referência Agrária (ARA) (mile 98)
- Museums and history: Museum of Fine Arts of São Paulo (mile 44), Ema Gordon Klabin Cultural Foundation (mile 48), Museum of Science Professor Mario Tolentino (mile 193), Museu Histórico de Jaboticabal (mile 259), André Matarazzo Museum of Arms, Vehicles and Machines Eduardo (mile 282)
- With kids: São Paulo Zoo (mile 40), Museum of Science Professor Mario Tolentino (mile 193)
São Paulo Zoo
Set in São Paulo's South Zone on 824,529 square meters of former Atlantic Forest, the São Paulo Zoo contains the spring of the Ipiranga Brook and about four kilometers of pathways.
Cinemateca Brasileira
The Cinemateca Brasileira is the Brazilian institution responsible for preserving the country's audiovisual production.
Museum of Fine Arts of São Paulo
A university museum in the Vila Mariana neighborhood of São Paulo, the Museum of Fine Arts of São Paulo opened in September 2007.
Ema Gordon Klabin Cultural Foundation
The Ema Gordon Klabin Cultural Foundation is an art museum in São Paulo, set up in 1978 as a not-for-profit private institution recognized as being of federal public interest.
Teatro Procópio Ferreira
Teatro Procópio Ferreira is a theater in São Paulo, Brazil, where audiences can catch live stage shows.
Parque Estadual da Assessoria de Referência Agrária (ARA)
The ARA State Park (Parque Estadual da ARA) in Valinhos, São Paulo state, covers about 65 acres and protects a small remnant of seasonal semideciduous forest.
Museum of Science Professor Mario Tolentino
Opened by the city of São Carlos in 2012, this science museum offers interactive exhibits and experiments in science, technology and art, named for professor and historian Mario Tolentino.
Museu Histórico de Jaboticabal
Run by the city of Jaboticabal, the Museu Histórico de Jaboticabal Aloísio de Almeida was created by law in 1965 and opened to the public on July 16, 1979, to preserve the town's historic and artistic heritage.
André Matarazzo Museum of Arms, Vehicles and Machines Eduardo
Known locally as the Museu do Automóvel, Bebedouro's private museum grew from Eduardo André Matarazzo's collection of vintage vehicles and also shows retired airliners outdoors, including a DC-3 and a Vickers Viscount.
When you get to Barretos
Museu Ruy Menezes
In Barretos, São Paulo, the Ruy Menezes Historical, Artistic and Folkloric Museum safeguards the city's memory through documents and objects from local history.
More drives to Barretos
- Araraquara to Barretos
- São Carlos to Barretos
- Limeira to Barretos
- Piracicaba to Barretos
- Poços de Caldas to Barretos
- Campinas to Barretos
From Santos to other places in Brazil
- Santos to Itanhaém
- Santos to Bragança Paulista
- Santos to Itu
- Santos to Limeira
- Santos to Mogi Guaçu
- Santos to Botucatu
Frequently asked questions
How long does it take to drive from Santos to Barretos?
About 6 h 9 min of driving without stops, over 311 miles.
What is the driving distance from Santos to Barretos?
About 311 miles (501 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Santos to Barretos drive?
The U.S. State Department rates Brazil Level 2: Exercise Increased Caution. Read the full advisory before you go.
Which highways go from Santos to Barretos?
In order: SP-160, SP-015, SP-348, SPA-102/330, SP-330, SP-310 and SP-326. The road-by-road table above shows the route miles for each one.
What are good stops between Santos and Barretos?
Closest to the road: São Paulo Zoo (zoo, mile 40, 0.8 mi from the route); Ema Gordon Klabin Cultural Foundation (art museum, mile 48, 1 mi from the route); Parque Estadual da Assessoria de Referência Agrária (ARA) (state park, mile 98, 0.9 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.