Santiago del Estero to San Antonio de los Cobres is about 373 road miles (600 km): roughly 7 h 43 min at the wheel if you don't stop.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Distance | 373 mi (600 km) |
|---|---|
| Time at the wheel, no stops | 7 h 43 min |
| Main roads, in order | RN34 → RN9 → RP59 → RP24 → RN51 |
| Provinces on the route | Santiago del Estero, Tucumán, Salta |
| Fuel estimate (car at 25 mpg) | about 14.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 2 |
What the drive from Santiago del Estero to San Antonio de los Cobres is like
RN34 (154 mi) and RN9 (102 mi) carry about 69% of the 373 miles. It runs through 3 provinces: Santiago del Estero, Tucumán, Salta. Of the 2 stops listed below, 1 are within a mile of the road.
Roads you'll take from Santiago del Estero to San Antonio de los Cobres
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–5 | 5 | Santiago del Estero |
| connecting roads | 5–9 | 4 | Santiago del Estero |
| RN34 | 9–163 | 154 | Santiago del Estero, Tucumán, Salta |
| RN9 | 163–265 | 102 | Salta |
| connecting roads | 265–267 | 2 | Salta |
| RP59 | 267–279 | 12 | Salta |
| connecting roads | 279–280 | 1 | Salta |
| RP24 | 280–286 | 6 | Salta |
| RN51 | 286–373 | 87 | Salta |
- Mile 111 of this route: Santiago del Estero → Tucumán (province line)
- Mile 121 of this route: Tucumán → Salta (province line)
Places worth a stop between Santiago del Estero and San Antonio de los Cobres
- Right off the route (under 1 mile): Tastil (mile 334)
- Museums and history: Museum of High Altitude Archaeology (mile 266), Tastil (mile 334)
Museum of High Altitude Archaeology
In Salta's historic center, the Museum of High Altitude Archaeology holds collections tied to Inca Capacocha ceremonies, mainly the Children of Llullaillaco mummies found in 1999 atop Llullaillaco volcano.
Tastil
Tastil is an archaeological site you'll find near Santa Rosa de Tastil, in Argentina's Salta Province.
More drives to San Antonio de los Cobres
- San Salvador de Jujuy to San Antonio de los Cobres
- Tafí Viejo to San Antonio de los Cobres
- San Miguel de Tucumán to San Antonio de los Cobres
- Catamarca to San Antonio de los Cobres
- La Rioja to San Antonio de los Cobres
- Sucre to San Antonio de los Cobres, Argentina
From Santiago del Estero to other places in Argentina
Frequently asked questions
How long is the drive from Santiago del Estero to San Antonio de los Cobres?
About 7 h 43 min of driving without stops, over 373 miles.
How far is San Antonio de los Cobres from Santiago del Estero by car?
About 373 miles (600 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Santiago del Estero to San Antonio de los Cobres?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
Which highways go from Santiago del Estero to San Antonio de los Cobres?
In order: RN34, RN9, RP59, RP24 and RN51. The road-by-road table above shows the route miles for each one.
What are good stops between Santiago del Estero and San Antonio de los Cobres?
Closest to the road: Museum of High Altitude Archaeology (museum, mile 266, 3 mi from the route); Tastil (historic site, mile 334, 0.4 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.