Santiago, Chile to Portillo is about 96 road miles (154 km): roughly 2 h 23 min at the wheel if you don't stop.
Full advisory: Chile. Advisory issued: Chile August 19, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Chile: “Use caution when walking or driving at night, especially if alone.”
| Distance | 96 mi (154 km) |
|---|---|
| Time at the wheel, no stops | 2 h 23 min |
| Main roads, in order | E-57 → E-61 → E-773 |
| Regions on the route | Región Metropolitana de Santiago, Valparaíso |
| Fuel estimate (car at 25 mpg) | about 3.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
What the drive from Santiago to Portillo is like
E-61 (6 mi) and E-773 (5 mi) carry about 11% of the 96 miles. It runs through 2 regions: Región Metropolitana de Santiago, Valparaíso. Of the 7 stops listed below, 2 are within a mile of the road.
Roads you'll take from Santiago to Portillo
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–7 | 7 | Región Metropolitana de Santiago |
| connecting roads | 7–9 | 2 | Región Metropolitana de Santiago |
| local roads | 9–45 | 36 | Región Metropolitana de Santiago, Valparaíso |
| E-57 | 45–49 | 4 | Valparaíso |
| connecting roads | 49–51 | 2 | Valparaíso |
| E-61 | 51–57 | 6 | Valparaíso |
| local roads | 57–91 | 34 | Valparaíso |
| E-773 | 91–96 | 5 | Valparaíso |
- Mile 36 of this route: Región Metropolitana de Santiago → Valparaíso (region line)
Breaking up the drive: stops between Santiago and Portillo
- Right off the route (under 1 mile): Santuario de Santa Teresa de Los Andes (mile 44), Museo Arqueológico de Los Andes (mile 50)
- Nature and outdoors: Laguna Piedra Roja (mile 16), Colina Thermal Baths (mile 22), Corazon Thermal Baths (mile 53), Lobo Thermal Baths (mile 58), Río Blanco National Reserve (mile 70)
- Museums and history: Museo Arqueológico de Los Andes (mile 50)
Laguna Piedra Roja
Laguna Piedra Roja is an artificial lagoon in Chicureo, in the Colina commune of Chile's Santiago Metropolitan Region.
Colina Thermal Baths
In the north of Chile's Santiago Metropolitan Region, the Colina Thermal Baths (Baños de Colina) are hot springs on the Colina River used for both medicinal and tourist purposes.
Santuario de Santa Teresa de Los Andes
Pilgrims come to the Santuario de Santa Teresa de Los Andes in Rinconada, Valparaíso Region, to venerate the relics of Saint Teresa of the Andes, Chile's first saint. The shrine was built to receive thousands of the faithful.
Museo Arqueológico de Los Andes
Opened in 1969 by Carlos Coros, the Los Andes Archaeological Museum occupies a 19th-century house and holds a collection tied to the Aconcagua culture and the Inca civilization.
Corazon Thermal Baths
In Chile's Valparaíso Region, the Corazón Thermal Baths (Baños Corazón) are hot springs whose waters have been used for medicinal purposes.
Lobo Thermal Baths
Thermal springs in Chile's Valparaíso Region, the Lobo Thermal Baths (Baños de Lobo) are used for both therapeutic soaking and tourism.
Río Blanco National Reserve
Río Blanco National Reserve is a protected area in Chile's Valparaíso Region, about 60 kilometers northeast of Santiago.
More drives to Portillo
- El Colorado to Portillo
- Viña del Mar to Portillo
- Valparaíso to Portillo
- Algarrobo to Portillo
- Coquimbo to Portillo
- Copiapó to Portillo
From Santiago to other places in Chile
- Santiago, Chile to Valparaíso
- Santiago, Chile to Quintay
- Santiago, Chile to Reñaca
- Santiago, Chile to La Serena
- Santiago, Chile to Vicuña
- Santiago, Chile to Pisco Elqui
Frequently asked questions
How long does it take to drive from Santiago, Chile to Portillo?
About 2 h 23 min of driving without stops, over 96 miles.
How far is Portillo from Santiago, Chile by car?
About 96 miles (154 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Santiago, Chile to Portillo?
The U.S. State Department rates Chile Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Santiago to Portillo use?
In order: E-57, E-61 and E-773. The road-by-road table above shows the route miles for each one.
What are good stops between Santiago and Portillo?
Closest to the road: Santuario de Santa Teresa de Los Andes (convent of discalced carmelite nuns, mile 44, 0.6 mi from the route); Museo Arqueológico de Los Andes (archaeological museum, mile 50, 0.8 mi from the route); Corazon Thermal Baths (hot spring, mile 53, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.