Plan on about 9 h 16 min of driving for the 464-mile (747 km) trip from Santa Rosa to Gualeguaychú, before any stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
| Total distance | 464 mi (747 km) |
|---|---|
| Drive time without stops | 9 h 16 min |
| Main roads, in order | RN5 → RP6 → RN12 → RN14 |
| Provinces on the route | La Pampa, Buenos Aires, Entre Ríos |
| Fuel estimate (car at 25 mpg) | about 18.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 6 |
How the Santa Rosa to Gualeguaychú drive plays out
RN5 (338 mi) and RN12 (47 mi) carry about 83% of the 464 miles. It runs through 3 provinces: La Pampa, Buenos Aires, Entre Ríos. None of the 6 stops below is right on the road, so plan each as a short side trip.
Road-by-road breakdown: Santa Rosa to Gualeguaychú
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–1 | 1 | La Pampa |
| RN5 | 1–339 | 338 | La Pampa, Buenos Aires |
| connecting roads | 339–341 | 2 | Buenos Aires |
| RP6 | 341–375 | 34 | Buenos Aires |
| RN12 | 375–422 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 422–459 | 37 | Entre Ríos |
| local roads | 459–464 | 5 | Entre Ríos |
- Mile 54 of this route: La Pampa → Buenos Aires (province line)
- Mile 392 of this route: Buenos Aires → Entre Ríos (province line)
Where to stop on the way to Gualeguaychú
- Nature and outdoors: Ciervo de los Pantanos National Park (mile 365)
- Museums and history: Museum of Contemporary Art Raúl Lozza (mile 260), Museo Pompeo Boggio (mile 280), Mercedes Cathedral (mile 317), Museum of Fine Arts Fernán Félix de Amador (mile 335)
Museum of Contemporary Art Raúl Lozza
Opened on October 27, 2003, in Alberti, Buenos Aires Province, this museum began with works donated by artist Raúl Lozza, co-founder of the Arte Concreto-Invención movement, and has permanent and temporary galleries and an auditorium.
Museo Pompeo Boggio
At the corner of Bolívar and Salta streets in Chivilcoy, Buenos Aires Province, Museo Pompeo Boggio is the town's municipal museum, run by the local culture department.
Mercedes Cathedral
The Catholic cathedral and minor basilica of Mercedes, Buenos Aires Province, serves as the seat of the Archdiocese of Mercedes-Luján.
Abadía de San Benito
On the outskirts of Luján, Abadía de San Benito is a Benedictine monastery of the Cono-Sur Congregation that became an abbey in 1950 before moving from Buenos Aires.
Museum of Fine Arts Fernán Félix de Amador
Luján's Museum of Fine Arts is named after Fernán Félix de Amador, the Argentine writer, poet and journalist born in the city.
Ciervo de los Pantanos National Park
Marsh deer give their name to Ciervo de los Pantanos National Park, a Ramsar Site in Campana, Buenos Aires province, where waterbirds are abundant.
When you get to Gualeguaychú
Gualeguaychú Cathedral
St. Joseph's Cathedral, also called Gualeguaychú Cathedral, serves as the cathedral church of the Roman Catholic Diocese of Gualeguaychú in Argentina.
More drives to Gualeguaychú
- Buenos Aires to Gualeguaychú
- La Plata to Gualeguaychú
- Mar del Plata to Gualeguaychú
- Bahía Blanca to Gualeguaychú
- Córdoba, Argentina to Gualeguaychú
- Montevideo to Gualeguaychú, Argentina
From Santa Rosa to other places in Argentina
- Santa Rosa to Tigre
- Santa Rosa to Berisso
- Santa Rosa to Rawson
- Santa Rosa to Capilla del Monte
- Santa Rosa to Villa Carlos Paz
- Santa Rosa to Mercedes, Uruguay
Frequently asked questions
How long is the drive from Santa Rosa to Gualeguaychú?
About 9 h 16 min of driving without stops, over 464 miles.
What is the driving distance from Santa Rosa to Gualeguaychú?
About 464 miles (747 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Santa Rosa to Gualeguaychú drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
What roads does the drive from Santa Rosa to Gualeguaychú use?
In order: RN5, RP6, RN12 and RN14. The road-by-road table above shows the route miles for each one.
What are good stops between Santa Rosa and Gualeguaychú?
Closest to the road: Museum of Contemporary Art Raúl Lozza (museum, mile 260, 2 mi from the route); Mercedes Cathedral (cathedral, mile 317, 2 mi from the route); Museum of Fine Arts Fernán Félix de Amador (museum, mile 335, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.