Plan on about 5 h 44 min of driving for the 237-mile (382 km) trip from San Salvador de Jujuy to Santa María, Argentina, before any stops.
Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”
| Distance | 237 mi (382 km) |
|---|---|
| Driving time, no stops | 5 h 44 min |
| Main roads, in order | RN66 → RN1V66 → RN34 → RN9 → RP59 → RN68 → RN40 |
| Provinces on the route | Jujuy, Salta, Tucumán, Catamarca |
| Fuel estimate (car at 25 mpg) | about 9.5 gal; actual use varies by vehicle and traffic |
| Stops listed below | 5 |
What the drive from San Salvador de Jujuy to Santa María is like
RN68 (109 mi) and RN40 (45 mi) carry about 65% of the 237 miles. It runs through 4 provinces: Jujuy, Salta, Tucumán, Catamarca. Of the 5 stops listed below, 2 are within a mile of the road.
The route from San Salvador de Jujuy to Santa María, road by road
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–2 | 2 | Jujuy |
| RN66 | 2–19 | 17 | Jujuy |
| RN1V66 | 19–26 | 7 | Jujuy |
| RN34 | 26–46 | 20 | Jujuy, Salta |
| RN9 | 46–70 | 24 | Salta |
| connecting roads | 70–71 | 1 | Salta |
| RP59 | 71–75 | 4 | Salta |
| connecting roads | 75–81 | 6 | Salta |
| RN68 | 81–190 | 109 | Salta |
| RN40 | 190–235 | 45 | Salta, Tucumán, Catamarca |
| local roads | 235–237 | 2 | Catamarca |
- Mile 32 of this route: Jujuy → Salta (province line)
- Mile 205 of this route: Salta → Tucumán (province line)
- Mile 229 of this route: Tucumán → Catamarca (province line)
Breaking up the drive: stops between San Salvador de Jujuy and Santa María
- Right off the route (under 1 mile): Our Lady of Rosary Cathedral, Cafayate (mile 190), Museo de la Vid y el Vino (mile 190)
- Museums and history: Basílica y Convento de San Francisco (Salta) (mile 70), Museo de Arte Contemporáneo de Salta (mile 70), Our Lady of Rosary Cathedral, Cafayate (mile 190), Museo de la Vid y el Vino (mile 190), Ruins of Quilmes (mile 220)
Basílica y Convento de San Francisco (Salta)
A Franciscan church and convent in Salta, the Basílica y Convento de San Francisco is one of the city's main sights, declared a National Historic Monument in 1941 and a minor basilica in 1992.
Museo de Arte Contemporáneo de Salta
Opened on June 26, 2004, the Museo de Arte Contemporáneo de Salta exhibits, studies and promotes contemporary art and serves as a hub for contemporary visual arts.
Our Lady of Rosary Cathedral, Cafayate
In the town of Cafayate, Salta Province, Our Lady of Rosary Cathedral is the seat of the Catholic bishopric of Cafayate, under the Archdiocese of Salta.
Museo de la Vid y el Vino
In Cafayate, Salta Province, the Museo de la Vid y el Vino is a museum devoted to grapevines and winemaking.
Ruins of Quilmes
In the Calchaquí Valleys of Tucumán Province, the Ruins of Quilmes mark a pre-Columbian settlement that covered about 74 acres, the largest in the country.
More drives to Santa María
- Río Cuarto to Santa María, Argentina
- Tafí Viejo to Santa María, Argentina
- Tupiza to Santa María, Argentina
From San Salvador de Jujuy to other places in Argentina
- San Salvador de Jujuy to Amaicha del Valle
- San Salvador de Jujuy to La Rioja
- San Salvador de Jujuy to Capilla del Monte
- San Salvador de Jujuy to San Antonio de los Cobres
- San Salvador de Jujuy to Llallagua, Bolivia
- San Salvador de Jujuy to San Pedro de Quemes Canton, Bolivia
Frequently asked questions
How long does it take to drive from San Salvador de Jujuy to Santa María, Argentina?
About 5 h 44 min of driving without stops, over 237 miles.
What is the driving distance from San Salvador de Jujuy to Santa María, Argentina?
About 237 miles (382 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the San Salvador de Jujuy to Santa María drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.
What roads does the drive from San Salvador de Jujuy to Santa María use?
In order: RN66, RN1V66, RN34, RN9, RP59, RN68 and RN40. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from San Salvador de Jujuy to Santa María?
Closest to the road: Basílica y Convento de San Francisco (Salta) (basilica, mile 70, 2 mi from the route); Museo de la Vid y el Vino (museum, mile 190, 0.1 mi from the route); Our Lady of Rosary Cathedral, Cafayate (cathedral, mile 190, 0.1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.