The Wayro route from San Antonio to Saltillo is 342 miles (550 km), about 5 h 59 min of driving without stops. The U.S.–Mexico border is at about mile 158 on this route, near the Laredo port of entry.
What the State Department tells travelers on this route:
- Nuevo León: “Those traveling between the U.S. border and Monterrey on highways 85/85D, 54, and 40/40D should exercise caution and avoid travel after dark.”
- Nuevo León: “Armed robberies and carjackings have occurred along these highways even during daylight hours.”
| Distance | 342 mi (550 km) |
|---|---|
| Driving time, no stops | 5 h 59 min |
| Main roads, in order | I-10 → I-35 → MEX-85 → MEX-85D → NL 100D → MEX-40D → MEX-40 |
| Border crossing | about mile 158 of this route, Texas → Tamaulipas (near the Laredo, TX port of entry) |
| Mexican states on the route | Tamaulipas (Level 4), Nuevo León (Level 2), Coahuila (Level 3) |
| Toll roads | MEX-85D, MEX-40D |
| Fuel estimate (car at 25 mpg) | about 13.7 gal; actual use varies by vehicle and traffic |
| Stops listed below | 3 |
Crossing into Mexico: what you need for Saltillo
| Passport | Passport book or passport card to enter Mexico by land |
|---|---|
| FMM entry permit | Required for this trip: Saltillo is well beyond the 12-mile (20 km) border zone where the permit is not needed |
| Temporary vehicle import permit (TIP) | Required for a U.S.-registered vehicle this far into Mexico |
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you cross |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
Crossing at Laredo
Laredo reaches Nuevo Laredo over several city-run bridges. Gateway to the Americas (Bridge I) handles pedestrians and cars and has SENTRI lanes, Juárez-Lincoln (Bridge II) takes cars and buses, and the World Trade Bridge is for commercial trucks.
What the drive from San Antonio to Saltillo is like
I-35 (144 mi) and MEX-85 (117 mi) carry about 76% of the 342 miles. The U.S. part of the drive runs through Texas for about 158 miles; after the border at Laredo you have about 184 miles left in Mexico. The Mexican leg uses MEX-85D, MEX-40D, toll highways (cuota). Of the 3 stops listed below, 2 are within a mile of the road.
The route from San Antonio to Saltillo, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–2 | 2 | Texas |
| I-10 | 2–12 | 10 | Texas |
| I-35 | 12–156 | 144 | Texas |
| connecting roads | 156–157 | 1 | Texas |
| local roads | 157–160 | 3 | Texas, Tamaulipas |
| MEX-85 | 160–277 | 117 | Tamaulipas, Nuevo León |
| MEX-85D | 277–281 | 4 | Nuevo León |
| connecting roads | 281–282 | 1 | Nuevo León |
| NL 100D | 282–305 | 23 | Nuevo León |
| connecting roads | 305–306 | 1 | Nuevo León |
| MEX-40D | 306–323 | 17 | Nuevo León, Coahuila |
| MEX-40 | 323–338 | 15 | Coahuila |
| local roads | 338–342 | 4 | Coahuila |
- Mile 158 of this route: Texas → Tamaulipas (international border)
- Mile 183 of this route: Tamaulipas → Nuevo León (state line)
- Mile 318 of this route: Nuevo León → Coahuila (state line)
Stops between San Antonio and Saltillo
- Right off the route (under 1 mile): Cathedral of San Agustin (mile 157), Parque la Junta (mile 158)
- Nature and outdoors: Lake Casa Blanca International State Park (mile 154), Parque la Junta (mile 158)
- Museums and history: Cathedral of San Agustin (mile 157)
Lake Casa Blanca International State Park
Set on a 1,680-acre reservoir in Laredo, minutes from the Mexican border, the park draws anglers after bass, crappie and catfish, along with swimmers, boaters and water-skiers. Trails, picnic areas and shoreline campsites fill the land side.
Cathedral of San Agustin
Facing San Agustín Plaza in downtown Laredo, the church was built between 1866 and 1872 and became the cathedral of the new Diocese of Laredo in 2000. Its clock tower was raised after 1919.
Parque la Junta
Parque la Junta is a baseball field in Nuevo Laredo, Tamaulipas, the Mexican border city across from Laredo, Texas, built in 1947.
When you get to Saltillo
Founded in 1577 as the Villa de Santiago del Saltillo, Coahuila's capital sits high on a plain backed by the Sierra de Zapalinamé. The city gave its name to the Saltillo sarape, and its cathedral, museums and nearby wineries such as Viñedos Zapa and Bodegas Capellanía make it an easy overnight stop on the way south.
- Catedral de Santiago: Begun in 1745, the cathedral blends Baroque and Churrigueresque styles and keeps about 45 colonial-era oil paintings inside. source
- Museo del Desierto: Opened in 1999, the museum explains Mexico's deserts with a T. rex, a hadrosaur and a Quetzalcoatlus, plus a live prairie dog colony. source
- Museo de las Aves de México: Its mounted birds represent about 75 percent of Mexico's bird species, displayed in a 19th-century building that was once a Jesuit school. source
Desert Museum
Opened in 1999, Saltillo's Museo del Desierto explores the deserts of Mexico across four pavilions, with skeletons of Tyrannosaurus rex and Quetzalcoatlus, a live prairie dog colony, a plant nursery, and a courtyard where simulated rain falls.
Saltillo Cathedral
Built between 1745 and 1800 in downtown Saltillo, the Cathedral of Santiago Apóstol has a carved stone facade with Solomonic, estípite, and Churrigueresque columns. Inside, look for an ornate altarpiece with a silver frontal and a pulpit carved with plant motifs.
More drives to Saltillo
- Brenham, TX to Saltillo
- Smithville, TX to Saltillo
- Austin, TX to Saltillo
- Marble Falls, TX to Saltillo
- Brownsville, TX to Saltillo
- Galveston, TX to Saltillo
From San Antonio to other places in Mexico
- San Antonio, TX to Ojinaga
- San Antonio, TX to Reynosa
- San Antonio, TX to Real de Catorce
- San Antonio, TX to Ciudad Juárez
- San Antonio, TX to Ciudad Victoria
- San Antonio, TX to Linares
All routes to Saltillo, border crossings and permits in one place: Driving to Saltillo, Mexico from the U.S.
Continue Your Adventure
Frequently asked questions
How long is the drive from San Antonio to Saltillo?
About 5 h 59 min of driving without stops, over 342 miles.
How far is Saltillo from San Antonio by car?
About 342 miles (550 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the San Antonio to Saltillo drive cross into Mexico?
At about mile 158 of this route, from Texas into Tamaulipas, near the Laredo port of entry.
Do I need a permit to drive my car from San Antonio to Saltillo?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car this far into Mexico. You also need Mexican auto insurance and a passport book or card. An FMM entry permit is required too.
Is it safe to drive from San Antonio to Saltillo?
The U.S. State Department rates Tamaulipas Level 4: Do Not Travel; Nuevo León Level 2: Exercise Increased Caution; Coahuila Level 3: Reconsider Travel (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from San Antonio to Saltillo use?
In order: I-10, I-35, MEX-85, MEX-85D, NL 100D, MEX-40D and MEX-40. The road-by-road table above shows the route miles and states for each one.
What are good stops between San Antonio and Saltillo?
Closest to the road: Lake Casa Blanca International State Park (park, mile 154, 3 mi from the route); Cathedral of San Agustin (catholic cathedral, mile 157, 0.3 mi from the route); Parque la Junta (park, mile 158, 0.8 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.