The Wayro route from Samaipata to Santiago de Chiquitos is 341 miles (548 km), about 8 h 48 min of driving without stops.
Full advisory: Bolivia. Advisory issued: Bolivia August 18, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Bolivia: “Most highways do not have shoulders, fences, or barriers, and there are few lane markings.”
| Distance by road | 341 mi (548 km) |
|---|---|
| Driving time, no stops | 8 h 48 min |
| Main roads, in order | F7 → F4 |
| Departments on the route | Santa Cruz |
| Fuel estimate (car at 25 mpg) | about 13.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
What the drive from Samaipata to Santiago de Chiquitos is like
F4 (249 mi) and F7 (68 mi) carry about 93% of the 341 miles. Of the 7 stops listed below, 2 are within a mile of the road.
Which roads connect Samaipata and Santiago de Chiquitos
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–1 | 1 | Santa Cruz |
| F7 | 1–69 | 68 | Santa Cruz |
| local roads | 69–78 | 9 | Santa Cruz |
| F4 | 78–242 | 164 | Santa Cruz |
| local roads | 242–246 | 4 | Santa Cruz |
| connecting roads | 246–247 | 1 | Santa Cruz |
| F4 | 247–332 | 85 | Santa Cruz |
| local roads | 332–341 | 9 | Santa Cruz |
What to see on the way from Samaipata to Santiago de Chiquitos
- Right off the route (under 1 mile): Jardín Botánico de Santa Cruz de la Sierra (mile 83), Santuario Mariano de la Torre (mile 302)
- Nature and outdoors: Curichi La Madre (mile 71), Jardín Botánico de Santa Cruz de la Sierra (mile 83)
- Museums and history: Museo Artecampo (mile 72), Museo de Arte Contemporáneo de Santa Cruz de la Sierra (mile 78), Parque nacional Histórico Santa Cruz La Vieja (mile 246)
- With kids: Zoológico de Fauna Sudamericana (mile 78)
Curichi La Madre
Officially a municipal protected area, Curichi La Madre is a wetland within the city of Santa Cruz de la Sierra in eastern Bolivia.
Museo Artecampo
In Santa Cruz de la Sierra, Museo Artecampo showcases Indigenous and folk art from Bolivia's lowlands. It is a project of a cooperative center for research, craft design and marketing.
Zoológico de Fauna Sudamericana
Santa Cruz de la Sierra's municipal zoo, named for Noel Kempff Mercado, focuses on South American wildlife and is one of the city's tourist attractions, with many native species.
Museo de Arte Contemporáneo de Santa Cruz de la Sierra
Founded on March 14, 1991, Santa Cruz de la Sierra's contemporary art museum stands at Sucre and Potosí streets, four blocks from Plaza 24 de Septiembre.
Jardín Botánico de Santa Cruz de la Sierra
The municipal botanical garden of Santa Cruz de la Sierra covers 217 hectares within the city.
Parque nacional Histórico Santa Cruz La Vieja
About 3 km south of San José de Chiquitos, Santa Cruz la Vieja is a historic national park protecting archaeological, historical, and natural features.
Santuario Mariano de la Torre
Also called the Chochís Sanctuary, this shrine to the Virgin of the Assumption stands 2 km from the village of Chochís in Roboré municipality, about 80 km east of San José de Chiquitos.
More drives to Santiago de Chiquitos
- Santa Cruz de la Sierra to Santiago de Chiquitos
- Concepción, Bolivia to Santiago de Chiquitos
- Villa Tunari to Santiago de Chiquitos
From Samaipata to other places in Bolivia
- Samaipata to Challapata
- Samaipata to San Juan, Bolivia
- Samaipata to Chochís
- Samaipata to Passo do Lontra, Brazil
- Samaipata to Putre, Chile
Frequently asked questions
How long is the drive from Samaipata to Santiago de Chiquitos?
About 8 h 48 min of driving without stops, over 341 miles.
How far is Santiago de Chiquitos from Samaipata by car?
About 341 miles (548 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Samaipata to Santiago de Chiquitos drive?
The U.S. State Department rates Bolivia Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Samaipata to Santiago de Chiquitos use?
In order: F7 and F4. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Samaipata to Santiago de Chiquitos?
Closest to the road: Curichi La Madre (park, mile 71, 2 mi from the route); Jardín Botánico de Santa Cruz de la Sierra (botanical garden, mile 83, 0.4 mi from the route); Santuario Mariano de la Torre (shrine, mile 302, 0.9 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.