Puerto Madryn to Esquel Road Trip: Route, Stops & Drive Time

By admin, 13 October, 2026

Plan on about 7 h 45 min of driving for the 414-mile (666 km) trip from Puerto Madryn to Esquel, before any stops.

U.S. State Department travel advisory: Argentina — Level 1, Exercise Normal Precautions

Full advisory: Argentina. Advisory issued: Argentina July 10, 2026; checked October 10, 2026.

On the roads, the State Department says:

Argentina: “Drivers should prepare in advance when taking long road trips and make sure to have adequate insurance coverage.”

Route from Puerto Madryn to Esquel with the 2 stops listed below (blue dots).

Total distance	414 mi (666 km)
Time at the wheel, no stops	7 h 45 min
Main roads, in order	RPA04 → RN3 → RN25 → RN40 → RN259
Provinces on the route	Chubut
Fuel estimate (car at 25 mpg)	about 16.6 gal; actual use varies by vehicle and traffic
Stops listed below	2

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Driving Puerto Madryn to Esquel: the shape of the trip

RN25 (315 mi) and RN40 (53 mi) carry about 89% of the 414 miles. Of the 2 stops listed below, 2 are within a mile of the road.

Puerto Madryn to Esquel: the road sequence

Road	Route miles (from–to)	Length, mi	Province
local roads	0–1	1	Chubut
RPA04	1–5	4	Chubut
RN3	5–39	34	Chubut
RN25	39–354	315	Chubut
RN40	354–407	53	Chubut
RN259	407–414	7	Chubut

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Stops between Puerto Madryn and Esquel

Right off the route (under 1 mile): Municipal Museum of Visual Arts (mile 39), Gaiman Regional Historical Museum (mile 49)
Museums and history: Municipal Museum of Visual Arts (mile 39), Gaiman Regional Historical Museum (mile 49)

Municipal Museum of Visual Arts

Mile 39 · Museum · 0.8 mi from the route

Trelew's Municipal Museum of Visual Arts is a fine arts museum in the city center, run by the local culture office, with exhibitions that change every month.

Gaiman Regional Historical Museum

Mile 49 · Museum · 0.6 mi from the route

Housed in Gaiman's former train station, the Gaiman Regional Historical Museum is run by the municipality with support from the Welsh association Asociación Galesa de Educación y Cultura Camwy.

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More drives to Esquel

From Puerto Madryn to other places in Argentina

Frequently asked questions

How long does it take to drive from Puerto Madryn to Esquel?

About 7 h 45 min of driving without stops, over 414 miles.

What is the driving distance from Puerto Madryn to Esquel?

About 414 miles (666 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.

Is it safe to drive from Puerto Madryn to Esquel?

The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions. Read the full advisory before you go.

What roads does the drive from Puerto Madryn to Esquel use?

In order: RPA04, RN3, RN25, RN40 and RN259. The road-by-road table above shows the route miles for each one.

What are good stops between Puerto Madryn and Esquel?

Closest to the road: Municipal Museum of Visual Arts (museum, mile 39, 0.8 mi from the route); Gaiman Regional Historical Museum (museum, mile 49, 0.6 mi from the route). All stops are described above.

How we put this guide together

Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.