Nashville to Des Moines Road Trip Guide: Scenic Stops

Did you know that the segment of Interstate 24 West between Nashville and the Kentucky border is built on a section of the historic Natchez Trace? This ancient path once connected the Mississippi River to the Tennessee Valley. Today, the 560-mile drive from Nashville, TN to Des Moines, IA takes roughly 9 hours without stops, but smart travelers know the real journey lies in the detours.

If you're wondering how long to drive Nashville, TN to Des Moines, IA, plan for at least two days if you want to truly experience the region. The answer to is it worth driving Nashville, TN to Des Moines, IA is a resounding yes, thanks to the blend of rolling hills, river valleys, and prairie landscapes.

Interstate driving is safe with frequent police patrols, but watch for deer crossings at dawn and dusk, especially in rural Illinois and Iowa. Rest areas are well-lit and have security cameras. Family-friendly stops include the St. Louis Zoo (free) and the Kansas City LEGOLAND, a slight detour west.

• Pet-friendly framework: Many motels like La Quinta and Super 8 allow pets; rest areas have designated pet walk areas.
• Fatigue management: Stop every 2 hours; the town of Vandalia, IL has a classic drive-in theater and a rest stop with picnic tables.
• Hidden off-route spots: The town of Nauvoo, IL (Mormon history) and the Iowa Machine Shed restaurant in Des Moines offer unique experiences.

For more tips on discovering offbeat attractions, check out how to find the best stops and hidden gems between cities.

The primary route is I-24 West from Nashville to Paducah, then I-57 North to I-64 West into St. Louis, and finally I-70 West to I-35 North into Des Moines. Alternatively, US-61 and US-36 offer a more scenic two-lane experience through small towns.

• Best stops Nashville, TN to Des Moines, IA include Metropolis, IL, Hannibal, MO, and the Amana Colonies in Iowa.
• Fuel costs average $3.50 per gallon; plan for 3–4 fill-ups depending on your vehicle.
• Tolls are minimal; only a few bridges in St. Louis have small fees.

Road quality is generally excellent on interstates, with well-maintained rest areas every 50 miles. However, secondary routes like MO-79 can have rough patches. For those wondering about things to do between Nashville, TN and Des Moines, IA, rest stops often feature local tourism kiosks.

From Nashville’s limestone valleys to the Mississippi River bluffs near Hannibal, the terrain transitions from Appalachian foothills to Midwestern plains. In Missouri, the Mark Twain National Forest offers hiking trails and scenic overlooks. Stop at the John J. Audubon Bridge over the Mississippi for panoramic views.

• Natural attractions: Land Between the Lakes National Recreation Area (KY), Pere Marquette State Park (IL).
• UNESCO World Heritage Sites: None directly on route, but Cahokia Mounds State Historic Site near St. Louis is a designated World Heritage Site worth a 1-hour detour.
• Local commerce: Amish markets in southern Iowa, antique shops in Hannibal, and barbecue joints in Paducah.