The Wayro route from Manta to Huaquillas is 268 miles (432 km), about 6 h 9 min of driving without stops.
- Level 4: Do Not Travel in Ecuador: Huaquillas and Arenillas, in El Oro province.
- Level 4: Do Not Travel in Ecuador: Duran, in Guayas province.
- Level 4: Do Not Travel in Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3).
- Level 3: Reconsider Travel in Ecuador: El Oro province, outside Huaquillas and Arenillas.
- Level 3: Reconsider Travel in Ecuador: Sucumbios, Manabi, Santa Elena, and Santo Domingo provinces.
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Ecuador. Advisory issued: Ecuador August 18, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Ecuador: “In rural areas, you may encounter livestock in the road.”
| Distance | 268 mi (432 km) |
|---|---|
| Time at the wheel, no stops | 6 h 9 min |
| Main roads, in order | E15 → E30 → E482 → E48 → E40 → E25 → E50 |
| Provinces on the route | Manabi, Guayas, Azuay, El Oro |
| Fuel estimate (car at 25 mpg) | about 10.7 gal; actual use varies by vehicle and traffic |
| Stops listed below | 3 |
The Manta–Huaquillas drive in a few lines
E25 (113 mi) and E482 (88 mi) carry about 75% of the 268 miles. It runs through 4 provinces: Manabi, Guayas, Azuay, El Oro. Of the 3 stops listed below, 1 are within a mile of the road.
Which roads connect Manta and Huaquillas
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–1 | 1 | Manabi |
| E15 | 1–6 | 5 | Manabi |
| E30 | 6–10 | 4 | Manabi |
| E482 | 10–98 | 88 | Manabi, Guayas |
| E48 | 98–113 | 15 | Guayas |
| connecting roads | 113–115 | 2 | Guayas |
| local roads | 115–123 | 8 | Guayas |
| E40 | 123–141 | 18 | Guayas |
| E25 | 141–254 | 113 | Guayas, Azuay, El Oro |
| E50 | 254–268 | 14 | El Oro |
- Mile 70 of this route: Manabi → Guayas (province line)
- Mile 204 of this route: Guayas → Azuay (province line)
- Mile 208 of this route: Azuay → El Oro (province line)
Breaking up the drive: stops between Manta and Huaquillas
- Right off the route (under 1 mile): Jardín Botánico de Guayaquil (mile 115)
- Nature and outdoors: Jardín Botánico de Guayaquil (mile 115)
- Museums and history: Museo Antropologico y de Arte Contemporaneo (mile 123), Presley Norton Museum (mile 123)
Jardín Botánico de Guayaquil
Living plant collections grown for conservation, research and education fill the Jardín Botánico de Guayaquil, a 5-hectare botanical garden in Guayaquil, Ecuador.
Museo Antropologico y de Arte Contemporaneo
Known as MAAC, the Museo Antropologico y de Arte Contemporaneo in Guayaquil, Ecuador, celebrates Ecuadorian, Latin American and pre-Columbian art and culture on the Malecón 2000 riverwalk.
Presley Norton Museum
In Guayaquil, the Presley Norton Museum holds archaeological artifacts, including pottery and figurines made by Ecuador's original settlers, and occasionally hosts film screenings and live music.
More drives to Huaquillas
From Manta to other places in Ecuador
- Manta to Alausi
- Manta to Baños
- Manta to Otavalo
- Manta to Puyo
- Manta to Ipiales, Colombia
- Manta to Tumbes, Peru
Frequently asked questions
How long does it take to drive from Manta to Huaquillas?
About 6 h 9 min of driving without stops, over 268 miles.
How far is Huaquillas from Manta by car?
About 268 miles (432 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Is it safe to drive from Manta to Huaquillas?
The U.S. State Department rates Ecuador Level 2: Exercise Increased Caution. Parts of this route are in or near areas rated Level 4: Do Not Travel (Ecuador: Huaquillas and Arenillas, in El Oro province; Ecuador: Duran, in Guayas province). Read the full advisory before you go.
What roads does the drive from Manta to Huaquillas use?
In order: E15, E30, E482, E48, E40, E25 and E50. The road-by-road table above shows the route miles for each one.
What are good stops between Manta and Huaquillas?
Closest to the road: Jardín Botánico de Guayaquil (botanical garden, mile 115, 0.8 mi from the route); Museo Antropologico y de Arte Contemporaneo (art museum, mile 123, 2 mi from the route); Presley Norton Museum (museum, mile 123, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.