Plan on about 11 h 54 min of driving for the 532-mile (856 km) trip from Loja to Mompiche, before any stops.
- Level 4: Do Not Travel in Ecuador: Duran, in Guayas province.
- Level 4: Do Not Travel in Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3).
- Level 3: Reconsider Travel in Ecuador: All areas south of Esmeraldas City, in Esmeraldas province.
- Level 3: Reconsider Travel in Ecuador: El Oro province, outside Huaquillas and Arenillas.
- Level 3: Reconsider Travel in Ecuador: Sucumbios, Manabi, Santa Elena, and Santo Domingo provinces.
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Ecuador. Advisory issued: Ecuador August 18, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Ecuador: “When traveling between provinces, it is recommended to travel during daylight.”
| Total distance | 532 mi (856 km) |
|---|---|
| Driving time, no stops | 11 h 54 min |
| Main roads, in order | E35 → E50 → E25 → E40 → E48 → E482 → E15 |
| Provinces on the route | Loja, El Oro, Azuay, Guayas, Manabi, Esmeraldas |
| Fuel estimate (car at 25 mpg) | about 21.3 gal; actual use varies by vehicle and traffic |
| Stops listed below | 2 |
On the road from Loja to Mompiche
E15 (160 mi) and E25 (106 mi) carry about 50% of the 532 miles. It runs through 6 provinces: Loja, El Oro, Azuay, Guayas, Manabi, Esmeraldas. Of the 2 stops listed below, 1 are within a mile of the road.
Road-by-road breakdown: Loja to Mompiche
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–12 | 12 | Loja |
| connecting roads | 12–19 | 7 | Loja |
| E35 | 19–43 | 24 | Loja |
| E50 | 43–120 | 77 | Loja, El Oro |
| E25 | 120–226 | 106 | El Oro, Azuay, Guayas |
| E40 | 226–243 | 17 | Guayas |
| local roads | 243–253 | 10 | Guayas |
| E48 | 253–268 | 15 | Guayas |
| E482 | 268–356 | 88 | Guayas, Manabi |
| local roads | 356–362 | 6 | Manabi |
| E15 | 362–377 | 15 | Manabi |
| local roads | 377–383 | 6 | Manabi |
| E15 | 383–528 | 145 | Manabi, Esmeraldas |
| local roads | 528–532 | 4 | Esmeraldas |
- Mile 83 of this route: Loja → El Oro (province line)
- Mile 158 of this route: El Oro → Azuay (province line)
- Mile 163 of this route: Azuay → Guayas (province line)
- Mile 297 of this route: Guayas → Manabi (province line)
- Mile 506 of this route: Manabi → Esmeraldas (province line)
What to see on the way from Loja to Mompiche
- Right off the route (under 1 mile): Jardín Botánico de Guayaquil (mile 251)
- Nature and outdoors: Jardín Botánico de Guayaquil (mile 251)
- Museums and history: Guayaquil Metropolitan Cathedral (mile 243)
Guayaquil Metropolitan Cathedral
In the center of Guayaquil, the Metropolitan Cathedral succeeds the church that served as the city's main cathedral when Guayaquil was founded.
Jardín Botánico de Guayaquil
Living plant collections grown for conservation, research and education fill the Jardín Botánico de Guayaquil, a 5-hectare botanical garden in Guayaquil, Ecuador.
More drives to Mompiche
- Papallacta to Mompiche
- Tena to Mompiche
- Baeza to Mompiche
- Cuenca to Mompiche
- Máncora to Mompiche, Ecuador
- Zorritos to Mompiche, Ecuador
From Loja to other places in Ecuador
- Loja to Alausi
- Loja to Agua Blanca
- Loja to Latacunga
- Loja to Puerto Cayo
- Loja to Baños
- Loja to Montecristi
Frequently asked questions
How long does it take to drive from Loja to Mompiche?
About 11 h 54 min of driving without stops, over 532 miles.
What is the driving distance from Loja to Mompiche?
About 532 miles (856 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Loja to Mompiche drive?
The U.S. State Department rates Ecuador Level 2: Exercise Increased Caution. Parts of this route are in or near areas rated Level 4: Do Not Travel (Ecuador: Duran, in Guayas province; Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3)). Read the full advisory before you go.
Which highways go from Loja to Mompiche?
In order: E35, E50, E25, E40, E48, E482 and E15. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Loja to Mompiche?
Closest to the road: Guayaquil Metropolitan Cathedral (cathedral, mile 243, 3 mi from the route); Jardín Botánico de Guayaquil (botanical garden, mile 251, 0.8 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.