Plan on about 8 h 4 min of driving for the 386-mile (621 km) trip from La Plata to Tacuarembó, Uruguay, before any stops. You cross from Argentina into Uruguay at about mile 239, at the Colón–Paysandú bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “Several of the main highways are particularly accident-ridden.”
| Distance | 386 mi (621 km) |
|---|---|
| Drive time without stops | 8 h 4 min |
| Main roads, in order | RN1 → AV1-N → RN9 → RP6 → RN12 → RN14 → RN135 |
| Border crossing | about mile 239, Argentina → Uruguay (the Colón–Paysandú bridge) |
| Regions on the route | Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Paysandú, Salto, Tacuarembó |
| Fuel estimate (car at 25 mpg) | about 15.4 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Getting across the Argentina–Uruguay border
The route crosses at about mile 239, at the Colón–Paysandú bridge, from Entre Ríos into Paysandú. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
The La Plata–Tacuarembó drive in a few lines
RN14 (94 mi) and RN12 (47 mi) carry about 37% of the 386 miles. The first 239 miles are in Argentina; the last 147 are in Uruguay. It runs through 6 regions: Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Paysandú, Salto, Tacuarembó. Of the 9 stops listed below, 4 are within a mile of the road.
Roads you'll take from La Plata to Tacuarembó
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–3 | 3 | Buenos Aires |
| RN1 | 3–33 | 30 | Buenos Aires, Ciudad de Buenos Aires |
| local roads | 33–37 | 4 | Ciudad de Buenos Aires |
| AV1-N | 37–42 | 5 | Ciudad de Buenos Aires |
| connecting roads | 42–45 | 3 | Ciudad de Buenos Aires |
| RN9 | 45–84 | 39 | Buenos Aires |
| connecting roads | 84–85 | 1 | Buenos Aires |
| RP6 | 85–89 | 4 | Buenos Aires |
| RN12 | 89–136 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 136–230 | 94 | Entre Ríos |
| RN135 | 230–238 | 8 | Entre Ríos |
| local roads | 238–386 | 148 | Entre Ríos, Paysandú, Salto, Tacuarembó |
- Mile 29 of this route: Buenos Aires → Ciudad de Buenos Aires (region line)
- Mile 45 of this route: Ciudad de Buenos Aires → Buenos Aires (region line)
- Mile 107 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 239 of this route: Entre Ríos → Paysandú (international border)
- Mile 348 of this route: Paysandú → Salto (region line)
- Mile 353 of this route: Salto → Paysandú (region line)
- Mile 363 of this route: Paysandú → Tacuarembó (region line)
Where to stop on the way to Tacuarembó
- Right off the route (under 1 mile): Museo de la Pasión Boquense (mile 32), Basílica del Santísimo Sacramento (mile 35), ESMA Museum and Site of Memory – Former Clandestine Center of Detention, Torture and Extermination (mile 43), Museo Carlos Gardel (mile 369)
- Nature and outdoors: Parque Natural Municipal Ribera Norte (mile 48), Pozo Hondo (mile 367)
- Museums and history: Museo de la Pasión Boquense (mile 32), Basílica del Santísimo Sacramento (mile 35), Casa Museo Bernardo Houssay (mile 36), Centro Cultural de la Ciencia (mile 39), ESMA Museum and Site of Memory – Former Clandestine Center of Detention, Torture and Extermination (mile 43), San Isidro Cathedral (mile 48), Museo Carlos Gardel (mile 369)
- With kids: Centro Cultural de la Ciencia (mile 39)
Museo de la Pasión Boquense
Football fans can dig into the history and personalities of Club Atlético Boca Juniors at the Museo de la Pasión Boquense, a themed soccer museum devoted to the club.
Basílica del Santísimo Sacramento
Consecrated in 1914, the Basílica del Santísimo Sacramento is a church at San Martín 1039 in the Retiro neighborhood of Buenos Aires.
Casa Museo Bernardo Houssay
Nobel laureate in medicine Bernardo Houssay lived with his family from 1925 to 1971 in this house at Viamonte 2790 in Buenos Aires, now a museum.
Centro Cultural de la Ciencia
Known as C3, the Centro Cultural de la Ciencia is a space for creating and sharing ideas about science as part of culture, housed in the Polo Científico Tecnológico in Buenos Aires.
ESMA Museum and Site of Memory – Former Clandestine Center of Detention, Torture and Extermination
Set in Buenos Aires on the former Navy Mechanics School grounds, one of the largest clandestine detention, torture and extermination centers of the last dictatorship, this site museum was declared UNESCO World Heritage in 2023.
Parque Natural Municipal Ribera Norte
On the Río de la Plata shore in Acassuso, San Isidro, Ribera Norte is a municipal nature park protecting green space within greater Buenos Aires.
San Isidro Cathedral
Main church of the Diocese of San Isidro, this cathedral stands on Del Libertador Avenue opposite Plaza Mitre, in the historic quarter of San Isidro in Buenos Aires province.
Pozo Hondo
Pozo Hondo is a waterfall in Uruguay's Tacuarembó department, located between the towns of Valle Edén and Tambores.
Museo Carlos Gardel
Dedicated to the life and work of Carlos Gardel, this museum is in Valle Edén, Tacuarembó department, 21 kilometers from the city of Tacuarembó.
Arriving in Tacuarembó
Museo de Geociencias
Cathedral of Tacuarembó
Saint Fructuosus Cathedral is the main Catholic church of Tacuarembó, Uruguay, and has been the seat of the local diocese since 1960.
Museo del Indio y del Gaucho Washington Escobar
The Museo del Indio y del Gaucho, a museum of the Indigenous people and the gaucho, is located in the city of Tacuarembó, Uruguay.
More drives to Tacuarembó
- Montevideo to Tacuarembó
- Maldonado to Tacuarembó
- Buenos Aires to Tacuarembó, Uruguay
- Rosario, Argentina to Tacuarembó, Uruguay
- Santa Fe to Tacuarembó, Uruguay
- Paraná to Tacuarembó, Uruguay
More drives from La Plata
- La Plata to Tigre
- La Plata to Luján
- La Plata to San Antonio de Areco
- La Plata to Arrecifes
- La Plata to Pergamino
- La Plata to Martínez
Continue Your Adventure
Frequently asked questions
How long is the drive from La Plata to Tacuarembó, Uruguay?
About 8 h 4 min of driving without stops, over 386 miles.
What is the driving distance from La Plata to Tacuarembó, Uruguay?
About 386 miles (621 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the La Plata to Tacuarembó drive cross the border?
At about mile 239, from Argentina into Uruguay, at the Colón–Paysandú bridge.
What do U.S. citizens need to drive from La Plata into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
What does the U.S. travel advisory say about the La Plata to Tacuarembó drive?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from La Plata to Tacuarembó use?
In order: RN1, AV1-N, RN9, RP6, RN12, RN14 and RN135. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from La Plata to Tacuarembó?
Closest to the road: Basílica del Santísimo Sacramento (basilica, mile 35, 0.3 mi from the route); ESMA Museum and Site of Memory – Former Clandestine Center of Detention, Torture and Extermination (museum, mile 43, 0.1 mi from the route); Museo Carlos Gardel (museum, mile 369, 0.4 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.