Guatapé to San Cipriano is about 344 road miles (554 km): roughly 8 h 41 min at the wheel if you don't stop.
- Level 4: Do Not Travel in Colombia: Valle del Cauca (excluding Cali).
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Colombia. Advisory issued: Colombia March 31, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Colombia: “Highways may not have lights or signs showing destinations.”
| Distance | 344 mi (554 km) |
|---|---|
| Time at the wheel, no stops | 8 h 41 min |
| Main roads, in order | 25BAN |
| Departments on the route | Antioquia, Caldas, Risaralda, Valle del Cauca |
| Fuel estimate (car at 25 mpg) | about 13.8 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
The Guatapé–San Cipriano drive in a few lines
25BAN (42 mi) carries about 12% of the 344 miles. It runs through 4 departments: Antioquia, Caldas, Risaralda, Valle del Cauca. Of the 8 stops listed below, 4 are within a mile of the road.
Guatapé to San Cipriano: the road sequence
| Road | Route miles (from–to) | Length, mi | Department |
|---|---|---|---|
| local roads | 0–52 | 52 | Antioquia |
| connecting roads | 52–55 | 3 | Antioquia |
| local roads | 55–60 | 5 | Antioquia |
| connecting roads | 60–61 | 1 | Antioquia |
| local roads | 61–66 | 5 | Antioquia |
| connecting roads | 66–67 | 1 | Antioquia |
| local roads | 67–75 | 8 | Antioquia |
| 25BAN | 75–117 | 42 | Antioquia |
| local roads | 117–344 | 227 | Antioquia, Caldas, Risaralda, Valle del Cauca |
- Mile 120 of this route: Antioquia → Caldas (department line)
- Mile 152 of this route: Caldas → Risaralda (department line)
- Mile 155 of this route: Risaralda → Caldas (department line)
- Mile 192 of this route: Caldas → Risaralda (department line)
- Mile 208 of this route: Risaralda → Valle del Cauca (department line)
Stops between Guatapé and San Cipriano
- Right off the route (under 1 mile): Catedral de Nuestra Señora de las Mercedes, Caldas (mile 66), Casa del Virrey (mile 209), Our Lady of Mount Carmel Cathedral, Valle del Cauca (mile 209), Basílica del Señor de los Milagros, Buga (mile 280)
- Museums and history: San Pedro Cemetery Museum (mile 51), Museo Entomológico Francisco Luis Gallego (mile 51), Catedral de Nuestra Señora de las Mercedes, Caldas (mile 66), Casa del Virrey (mile 209), Our Lady of Mount Carmel Cathedral, Valle del Cauca (mile 209), Basílica del Señor de los Milagros, Buga (mile 280)
San Pedro Cemetery Museum
Built in 1842 and named a museum in 1998, Medellín's San Pedro Cemetery Museum was declared a national monument of Colombia in 1999.
Museo Entomológico Francisco Luis Gallego
Museo Entomológico Francisco Luis Gallego is a nonprofit natural history museum in Medellín specializing in insects.
University of Medellín Theater
With 1,702 seats, the University of Medellín Theater in Medellín, Colombia, hosts national and international plays and shows.
Teatro al aire libre Carlos Vieco
On the north slope of Cerro Nutibara in Medellín, this Greek-inspired open-air theater opened in 1984 and honors Antioquian composer Carlos Vieco Ortiz.
Catedral de Nuestra Señora de las Mercedes, Caldas
This Catholic cathedral in the Colombian municipality of Caldas is dedicated to Our Lady of Mercy and serves as the seat of the bishop of the Diocese of Caldas.
Casa del Virrey
A colonial-era building in Cartago, Casa del Virrey takes its name from the popular tradition that it was built to receive Viceroy José Manuel de Ezpeleta.
Our Lady of Mount Carmel Cathedral, Valle del Cauca
Two blocks from Bolívar Park in Cartago, Valle del Cauca, the Cathedral of Our Lady of Mount Carmel stands out for a bell tower set twenty meters apart from the church.
Basílica del Señor de los Milagros, Buga
In Guadalajara de Buga, Colombia, the Basílica del Señor de los Milagros is a minor basilica dedicated to the Lord of Miracles of Buga.
More drives to San Cipriano
- Ibagué to San Cipriano
- Girardot City to San Cipriano
- Bogotá to San Cipriano
- Zipaquirá to San Cipriano
- Villavicencio to San Cipriano
- Tunja to San Cipriano
From Guatapé to other places in Colombia
Frequently asked questions
How long does it take to drive from Guatapé to San Cipriano?
About 8 h 41 min of driving without stops, over 344 miles.
What is the driving distance from Guatapé to San Cipriano?
About 344 miles (554 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Guatapé to San Cipriano drive?
The U.S. State Department rates Colombia Level 3: Reconsider Travel. Parts of this route are in or near areas rated Level 4: Do Not Travel (Colombia: Valle del Cauca (excluding Cali)). Read the full advisory before you go.
Where can you stop on the way from Guatapé to San Cipriano?
Closest to the road: Catedral de Nuestra Señora de las Mercedes, Caldas (cathedral, mile 66, 0.2 mi from the route); Casa del Virrey (museum, mile 209, 0.4 mi from the route); Our Lady of Mount Carmel Cathedral, Valle del Cauca (cathedral, mile 209, 0.4 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.