Guano to Puerto Cayo is about 250 road miles (403 km): roughly 5 h 38 min at the wheel if you don't stop.
- Level 4: Do Not Travel in Ecuador: Duran, in Guayas province.
- Level 4: Do Not Travel in Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3).
- Level 3: Reconsider Travel in Ecuador: Sucumbios, Manabi, Santa Elena, and Santo Domingo provinces.
This route passes through or near an area the State Department rates Do Not Travel. Read the full advisory before you plan this drive: Ecuador. Advisory issued: Ecuador August 18, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Ecuador: “Slow-moving buses and trucks frequently stop in the middle of the road unexpectedly.”
| Total distance | 250 mi (403 km) |
|---|---|
| Drive time without stops | 5 h 38 min |
| Main roads, in order | E35 → E487 → E40 → E48 → E482 → E483 |
| Provinces on the route | Chimborazo, Bolivar, Guayas, Cañar, Manabi |
| Fuel estimate (car at 25 mpg) | about 10.0 gal; actual use varies by vehicle and traffic |
| Stops listed below | 3 |
Driving Guano to Puerto Cayo: the shape of the trip
E487 (86 mi) and E482 (63 mi) carry about 60% of the 250 miles. It runs through 5 provinces: Chimborazo, Bolivar, Guayas, Cañar, Manabi. Of the 3 stops listed below, 1 are within a mile of the road.
Roads you'll take from Guano to Puerto Cayo
| Road | Route miles (from–to) | Length, mi | Province |
|---|---|---|---|
| local roads | 0–12 | 12 | Chimborazo |
| E35 | 12–18 | 6 | Chimborazo |
| connecting roads | 18–21 | 3 | Chimborazo |
| E487 | 21–107 | 86 | Chimborazo, Bolivar, Guayas, Cañar |
| local roads | 107–111 | 4 | Cañar |
| E40 | 111–147 | 36 | Guayas |
| local roads | 147–157 | 10 | Guayas |
| E48 | 157–171 | 14 | Guayas |
| E482 | 171–234 | 63 | Guayas, Manabi |
| E483 | 234–250 | 16 | Manabi |
- Mile 72 of this route: Chimborazo → Bolivar (province line)
- Mile 80 of this route: Bolivar → Chimborazo (province line)
- Mile 86 of this route: Chimborazo → Guayas (province line)
- Mile 94 of this route: Guayas → Cañar (province line)
- Mile 111 of this route: Cañar → Guayas (province line)
- Mile 200 of this route: Guayas → Manabi (province line)
Where to stop on the way to Puerto Cayo
- Right off the route (under 1 mile): Jardín Botánico de Guayaquil (mile 155)
- Nature and outdoors: Laguna de Colta (mile 21), Jardín Botánico de Guayaquil (mile 155)
- Museums and history: Museo Antropologico y de Arte Contemporaneo (mile 147)
Laguna de Colta
Laguna de Colta is a lake of about 275 hectares in Colta canton, Chimborazo province, in Ecuador's central highlands, home to native birds and many kinds of colorful fish.
Museo Antropologico y de Arte Contemporaneo
Known as MAAC, the Museo Antropologico y de Arte Contemporaneo in Guayaquil, Ecuador, celebrates Ecuadorian, Latin American and pre-Columbian art and culture on the Malecón 2000 riverwalk.
Jardín Botánico de Guayaquil
Living plant collections grown for conservation, research and education fill the Jardín Botánico de Guayaquil, a 5-hectare botanical garden in Guayaquil, Ecuador.
More drives to Puerto Cayo
- Alausi to Puerto Cayo
- Mindo to Puerto Cayo
- Riobamba to Puerto Cayo
- Baños to Puerto Cayo
- Quito to Puerto Cayo
- Tababela to Puerto Cayo
From Guano to other places in Ecuador
Frequently asked questions
How long is the drive from Guano to Puerto Cayo?
About 5 h 38 min of driving without stops, over 250 miles.
What is the driving distance from Guano to Puerto Cayo?
About 250 miles (403 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
What does the U.S. travel advisory say about the Guano to Puerto Cayo drive?
The U.S. State Department rates Ecuador Level 2: Exercise Increased Caution. Parts of this route are in or near areas rated Level 4: Do Not Travel (Ecuador: Duran, in Guayas province; Ecuador: In Guayaquil: Nueva Prosperina and Pascuales districts, and all areas south of Portete de Tarqui Avenue (areas north of the avenue are Level 3)). Read the full advisory before you go.
What roads does the drive from Guano to Puerto Cayo use?
In order: E35, E487, E40, E48, E482 and E483. The road-by-road table above shows the route miles for each one.
What are good stops between Guano and Puerto Cayo?
Closest to the road: Laguna de Colta (lagoon, mile 21, 1 mi from the route); Museo Antropologico y de Arte Contemporaneo (art museum, mile 147, 2 mi from the route); Jardín Botánico de Guayaquil (botanical garden, mile 155, 0.8 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.