The Wayro route from Guanajuato to San Blas is 328 miles (528 km), about 5 h 30 min of driving without stops.
| Distance | 328 mi (528 km) |
|---|---|
| Driving time, no stops | 5 h 30 min |
| Main roads, in order | MEX-110D → MEX-45 → MEX-45D → MEX-80 → MEX-80D → MEX-15D → MEX-15 → NAY 12 |
| Mexican states on the route | Guanajuato, Jalisco, Nayarit |
| Toll roads (as marked in OpenStreetMap) | MEX-110D, MEX-45D, MEX-80D, MEX-90D |
| Fuel estimate (car at 25 mpg) | about 13.1 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
On the road from Guanajuato to San Blas
MEX-15D (149 mi) and MEX-80D (85 mi) carry about 71% of the 328 miles. It runs through 3 states: Guanajuato, Jalisco, Nayarit. OpenStreetMap marks tolled sections on MEX-110D, MEX-45D and MEX-80D. Of the 8 stops listed below, 2 are within a mile of the road.
Which roads connect Guanajuato and San Blas
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–4 | 4 | Guanajuato |
| MEX-110D | 4–12 | 8 | Guanajuato |
| MEX-45 | 12–25 | 13 | Guanajuato |
| connecting roads | 25–26 | 1 | Guanajuato |
| MEX-45D | 26–63 | 37 | Guanajuato, Jalisco |
| MEX-80 | 63–78 | 15 | Jalisco |
| MEX-80D | 78–163 | 85 | Jalisco |
| MEX-15D | 163–176 | 13 | Jalisco |
| MEX-15 | 176–185 | 9 | Jalisco |
| MEX-15D | 185–321 | 136 | Jalisco, Nayarit |
| NAY 12 | 321–326 | 5 | Nayarit |
| local roads | 326–328 | 2 | Nayarit |
- Mile 46 of this route: Guanajuato → Jalisco (state line)
- Mile 233 of this route: Jalisco → Nayarit (state line)
Stops between Guanajuato and San Blas
- Right off the route (under 1 mile): Parque Metropolitano de Guadalajara (mile 174), Museo Interpretativo del Paisaje Agavero y la Minería (mile 214)
- Nature and outdoors: Parque Metropolitano de Guadalajara (mile 174)
- Museums and history: Cathedral Basilica of San Juan de los Lagos (mile 83), Museo Regional de la Ceramica, Tlaquepaque (mile 165), Guadalajara Cathedral (mile 169), Universidad de Guadalajara. Museo de las Artes (mile 170), Guachimontones (mile 198), Museo Interpretativo del Paisaje Agavero y la Minería (mile 214), Museo Regional de Nayarit (mile 295)
Cathedral Basilica of San Juan de los Lagos
Raised between 1732 and 1769, the cathedral basilica of San Juan de los Lagos draws pilgrims from far away who come to visit the small image of the Virgin kept inside.
Museo Regional de la Ceramica, Tlaquepaque
Tlaquepaque has two main ceramics museums, and this is one of them: the Museo Regional de la Cerámica, on Independencia Street in the center of town. The other is the Pantaleón Panduro Museum.
Guadalajara Cathedral
In the Centro of Guadalajara, the Cathedral of the Assumption of Our Lady is the seat of the Archdiocese of Guadalajara and a minor basilica.
Universidad de Guadalajara. Museo de las Artes
The University of Guadalajara's Museo de las Artes, known as MUSA, opened on October 10, 1994, and was expanded in 2013.
Parque Metropolitano de Guadalajara
Zapopan's Parque Metropolitano de Guadalajara is a public park in Jalisco with a busy event calendar that includes open-air film screenings, live concerts and food festivals.
Guachimontones
Western Mexico's first large population center, according to INAH, took shape near Teuchitlán around 1000 BC. Guachimontones stands out for its round architecture, with roughly 40 circular structures across the site.
Museo Interpretativo del Paisaje Agavero y la Minería
The Museo Interpretativo del Paisaje Agavero y la Minería, an interpretive museum of agave landscape and mining, is located in the municipality of Magdalena, Mexico.
Museo Regional de Nayarit
In the city of Tepic, the Museo Regional de Nayarit focuses on the different cultural traditions of pre-Hispanic Nayarit.
More drives to San Blas
- Guadalajara to San Blas
- Tepatitlán to San Blas
- San Juan de los Lagos to San Blas
- Zamora to San Blas
- Colima to San Blas
- Lagos de Moreno to San Blas
From Guanajuato to other places in Mexico
- Guanajuato to Amatitán
- Guanajuato to Tequila
- Guanajuato to Jerez, Zacatecas
- Guanajuato to Sombrerete
- Guanajuato to El Rosario, Sinaloa
- Guanajuato to San Ignacio, Sinaloa
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Guanajuato to San Blas?
About 5 h 30 min of driving without stops, over 328 miles.
How far is San Blas from Guanajuato by car?
About 328 miles (528 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guanajuato to San Blas?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guanajuato to San Blas?
The U.S. State Department rates Guanajuato Level 3: Reconsider Travel; Jalisco Level 3: Reconsider Travel; Nayarit Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guanajuato to San Blas use?
In order: MEX-110D, MEX-45, MEX-45D, MEX-80, MEX-80D, MEX-15D, MEX-15 and NAY 12. The road-by-road table above shows the route miles for each one.
What are good stops between Guanajuato and San Blas?
Closest to the road: Museo Regional de la Ceramica, Tlaquepaque (museum, mile 165, 1 mi from the route); Parque Metropolitano de Guadalajara (park, mile 174, 0.9 mi from the route); Museo Interpretativo del Paisaje Agavero y la Minería (museum, mile 214, 0.5 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.