The Wayro route from Guanajuato to Apizaco is 280 miles (450 km), about 4 h 45 min of driving without stops.
| Distance | 280 mi (450 km) |
|---|---|
| Driving time, no stops | 4 h 45 min |
| Main roads, in order | MEX-110 → MEX-45 → MEX-45D → MEX-47D → MEX-57D → MEX-M40D → MEX-136 |
| Mexican states on the route | Guanajuato (Level 3), Querétaro (Level 2), State of Mexico (Level 2), Hidalgo (Level 2), Tlaxcala (Level 2) |
| Toll roads | MEX-45D, MEX-43D, MEX-47D, MEX-57D, MEX-M40D |
| Fuel estimate (car at 25 mpg) | about 11.2 gal; actual use varies by vehicle and traffic |
| Stops listed below | 7 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Guanajuato to Apizaco is like
MEX-M40D (88 mi) and MEX-47D (52 mi) carry about 50% of the 280 miles. MEX-45D, MEX-47D, MEX-57D, MEX-M40D are toll highways (cuota); MEX-110, MEX-45, MEX-136 are free federal roads (libre). It runs through 5 states: Guanajuato, Querétaro, State of Mexico, Hidalgo, Tlaxcala. None of the 7 stops below is right on the road, so plan each as a short side trip.
The route from Guanajuato to Apizaco, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Guanajuato |
| MEX-110 | 1–7 | 6 | Guanajuato |
| local roads | 7–13 | 6 | Guanajuato |
| MEX-45 | 13–23 | 10 | Guanajuato |
| connecting roads | 23–24 | 1 | Guanajuato |
| MEX-45D | 24–75 | 51 | Guanajuato |
| connecting roads | 75–76 | 1 | Guanajuato |
| MEX-47D | 76–128 | 52 | Guanajuato, Querétaro |
| MEX-57D | 128–163 | 35 | Querétaro, State of Mexico |
| connecting roads | 163–164 | 1 | Hidalgo |
| MEX-M40D | 164–252 | 88 | Hidalgo, State of Mexico, Tlaxcala |
| MEX-136 | 252–279 | 27 | Tlaxcala |
| local roads | 279–280 | 1 | Tlaxcala |
- Mile 88 of this route: Guanajuato → Querétaro (state line)
- Mile 130 of this route: Querétaro → State of Mexico (state line)
- Mile 163 of this route: State of Mexico → Hidalgo (state line)
- Mile 193 of this route: Hidalgo → State of Mexico (state line)
- Mile 207 of this route: State of Mexico → Hidalgo (state line)
- Mile 224 of this route: Hidalgo → State of Mexico (state line)
- Mile 236 of this route: State of Mexico → Hidalgo (state line)
- Mile 244 of this route: Hidalgo → Tlaxcala (state line)
Stops between Guanajuato and Apizaco
- Nature and outdoors: Cerro de las Campanas (mile 87), El Cimatario National Park (mile 93)
- Museums and history: Tula (mile 175), Museo Arqueológico de Apaxco (mile 191), Teotihuacan (mile 224)
Cerro de las Campanas
Rising within Querétaro City, the Cerro de las Campanas is a hill that is protected as a Mexican national park.
El Cimatario National Park
El Cimatario National Park protects about 24 square kilometers of land just south of the city of Santiago de Querétaro.
Tula
Once the Toltec capital, the Tula archaeological zone is best known for its Atlantes, basalt warrior figures over four meters (13 feet) tall crowning the main pyramid. Visitors also see a ball court, the Burnt Palace and the Coatepantli wall, carved with snakes devouring skeletons.
Museo Arqueológico de Apaxco
Founded in 1985, the Museo Arqueológico de Apaxco sits across from the parish church of San Francisco de Asís and beside the town hall in Apaxco, State of Mexico.
Church and former convent of Todos los Santos
Franciscan friars built this fortress-style convent in Zempoala, and the complex still keeps the classic layout of atrium, church, open chapel and cloister. It pairs well with a drive through the area's old pulque haciendas.
Teotihuacan
Built between the 1st and 7th centuries AD, this UNESCO-listed ancient city lines the Avenue of the Dead, where you can walk between the Pyramid of the Sun, the Pyramid of the Moon and the Temple of the Feathered Serpent.
Aqueduct of Padre Tembleque
Built by Franciscan friar Francisco de Tembleque between 1554 and 1572, this 16th-century water system runs more than 48 km between Zempoala and Otumba. Its tallest arcade at Tepeyahualco reaches almost 40 meters, and UNESCO listed it in 2015.
When you get to Apizaco
Basílica de Nuestra Señora de las Misericordias, Apizaco
In the city of Apizaco, this Catholic basilica (Basílica de Nuestra Señora de la Misericordia) was begun in the third decade of the 20th century and completed in 1961.
Museo Casa de Piedra
Apizaco's old railroad station, dating from 1916, now houses the Museo Casa de Piedra. Inside, photographs and documents trace the town's history, especially its long ties to the railroads.
Ex Convento de Santa María de la Concepción Atlihuetzia
The ruined walls of this 16th-century Franciscan convent in Atlihuetzia rise as high as 21 meters beside the 17th-century Purísima Concepción church. The site also holds a sanctuary to Cristóbal, honored as the first Catholic child martyr in the Americas.
More drives to Apizaco
- Mexico City to Apizaco
- Tepotzotlán to Apizaco
- Cuautla to Apizaco
- Toluca to Apizaco
- Cuernavaca to Apizaco
- Taxco to Apizaco
From Guanajuato to other places in Mexico
- Guanajuato to Amatitán
- Guanajuato to Tequila
- Guanajuato to Jerez, Zacatecas
- Guanajuato to Sombrerete
- Guanajuato to El Rosario, Sinaloa
- Guanajuato to San Ignacio, Sinaloa
Continue Your Adventure
Frequently asked questions
How long is the drive from Guanajuato to Apizaco?
About 4 h 45 min of driving without stops, over 280 miles.
How far is Apizaco from Guanajuato by car?
About 280 miles (450 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Guanajuato to Apizaco?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Guanajuato to Apizaco?
The U.S. State Department rates Guanajuato Level 3: Reconsider Travel; Querétaro Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Guanajuato to Apizaco use?
In order: MEX-110, MEX-45, MEX-45D, MEX-47D, MEX-57D, MEX-M40D and MEX-136. The road-by-road table above shows the route miles and states for each one.
What are good stops between Guanajuato and Apizaco?
Closest to the road: Tula (archaeological site, mile 175, 1 mi from the route); Museo Arqueológico de Apaxco (museum, mile 191, 3 mi from the route); Aqueduct of Padre Tembleque (aqueduct, mile 226, 2 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.