The Wayro route from Cuajinicuilapa to Tlacotalpan is 423 miles (681 km), about 9 h 26 min of driving without stops.
| Total distance | 423 mi (681 km) |
|---|---|
| Driving time, no stops | 9 h 26 min |
| Main roads, in order | MEX-200 → MEX-125 → MEX-135D → MEX-150 → MEX-150D → MEX-175 |
| Mexican states on the route | Guerrero, Oaxaca, Puebla, Veracruz |
| Toll roads (as marked in OpenStreetMap) | MEX-135D, MEX-150D, MEX-145D |
| Fuel estimate (car at 25 mpg) | about 16.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
How the Cuajinicuilapa to Tlacotalpan drive plays out
MEX-125 (142 mi) and MEX-135D (65 mi) carry about 49% of the 423 miles. It runs through 4 states: Guerrero, Oaxaca, Puebla, Veracruz. OpenStreetMap marks tolled sections on MEX-135D, MEX-150D and MEX-145D. Of the 8 stops listed below, 2 are within a mile of the road.
Road-by-road breakdown: Cuajinicuilapa to Tlacotalpan
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| MEX-200 | 0–9 | 9 | Guerrero, Oaxaca |
| local roads | 9–30 | 21 | Oaxaca |
| MEX-125 | 30–172 | 142 | Oaxaca |
| connecting roads | 172–175 | 3 | Oaxaca |
| local roads | 175–185 | 10 | Oaxaca |
| MEX-135D | 185–250 | 65 | Oaxaca, Puebla |
| connecting roads | 250–251 | 1 | Puebla |
| local roads | 251–255 | 4 | Puebla |
| MEX-150 | 255–289 | 34 | Puebla, Veracruz |
| connecting roads | 289–290 | 1 | Veracruz |
| MEX-150D | 290–341 | 51 | Veracruz |
| local roads | 341–393 | 52 | Veracruz |
| MEX-175 | 393–423 | 30 | Veracruz |
- Mile 7 of this route: Guerrero → Oaxaca (state line)
- Mile 227 of this route: Oaxaca → Puebla (state line)
- Mile 276 of this route: Puebla → Veracruz (state line)
Breaking up the drive: stops between Cuajinicuilapa and Tlacotalpan
- Right off the route (under 1 mile): Huamelulpan (mile 149), Museo del Valle de Tehuacán (mile 253)
- Nature and outdoors: Tehuacán-Cuicatlán Biosphere Reserve (mile 237), Cañón del Río Blanco National Park (mile 286)
- Museums and history: Huamelulpan (mile 149), Museo del Valle de Tehuacán (mile 253), Orizaba Cathedral (mile 294), Veracruz State Art Museum (mile 296), Cathedral of Córdoba, Veracruz (mile 308), Huatusco (mile 334)
Huamelulpan
Huamelulpan is an archaeological site of the Mixtec culture in San Martín Huamelulpan, about 96 km northwest of Oaxaca city, set at roughly 2,218 meters and occupied from the Preclassic to the Postclassic periods.
Tehuacán-Cuicatlán Biosphere Reserve
In 2018 UNESCO inscribed the arid Tehuacán-Cuicatlán Valley, which spans Puebla and Oaxaca, as a mixed World Heritage site. A major center of cactus diversity, it also keeps ancient canals, terraces and dams.
Museo del Valle de Tehuacán
Inside an 18th-century former Carmelite convent in Tehuacán, the Valley of Tehuacán Museum opened in 2002 and focuses on the history of corn and its ties to the valley's early peoples.
Cañón del Río Blanco National Park
Protected as a national park by Mexico's government, Cañón del Río Blanco is a natural area in Veracruz state.
Orizaba Cathedral
The Cathedral of St. Michael the Archangel is the main Catholic church of Orizaba, in the state of Veracruz, and the seat of the Diocese of Orizaba.
Veracruz State Art Museum
Housed in Orizaba's 18th-century former Oratorio of San Felipe Neri, later a hospital and then a jail, the Veracruz State Art Museum (Museo de Arte del Estado) holds more than 700 works, including 36 by Diego Rivera.
Cathedral of Córdoba, Veracruz
Built in the first half of the 17th century, Córdoba's Immaculate Conception Cathedral is the city's main church; look up to see its octagonal dome covered in tiles, finished in a neoclassical style.
Huatusco
Above the Atoyac River in Carrillo Puerto, Cuauhtochco has a Mexica-era temple that still keeps original surface finishes. Expect no visitor facilities, and consider hiring a local guide.
More drives to Tlacotalpan
- Puebla to Tlacotalpan
- Cholula to Tlacotalpan
- Zacatelco to Tlacotalpan
- Chiautempan to Tlacotalpan
- Tlaxcala to Tlacotalpan
- Huejotzingo to Tlacotalpan
From Cuajinicuilapa to other places in Mexico
- Cuajinicuilapa to Capulalpam de Méndez
- Cuajinicuilapa to Ixcateopan
- Cuajinicuilapa to Malinalco
- Cuajinicuilapa to Tlayacapan
- Cuajinicuilapa to San Miguel, Morelos
- Cuajinicuilapa to Chipilo
Continue Your Adventure
Frequently asked questions
How long is the drive from Cuajinicuilapa to Tlacotalpan?
About 9 h 26 min of driving without stops, over 423 miles.
What is the driving distance from Cuajinicuilapa to Tlacotalpan?
About 423 miles (681 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Cuajinicuilapa to Tlacotalpan?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Cuajinicuilapa to Tlacotalpan?
The U.S. State Department rates Guerrero Level 4: Do Not Travel; Oaxaca Level 2: Exercise Increased Caution; Puebla Level 2: Exercise Increased Caution; Veracruz Level 2: Exercise Increased Caution (advisory issued May 29, 2026). Read the full advisory before you go.
Which highways go from Cuajinicuilapa to Tlacotalpan?
In order: MEX-200, MEX-125, MEX-135D, MEX-150, MEX-150D and MEX-175. The road-by-road table above shows the route miles for each one.
Where can you stop on the way from Cuajinicuilapa to Tlacotalpan?
Closest to the road: Huamelulpan (archaeological site, mile 149, 0.8 mi from the route); Museo del Valle de Tehuacán (museum, mile 253, 0.2 mi from the route); Veracruz State Art Museum (art museum, mile 296, 1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.