Cholula to Palizada Road Trip: Route, Stops & Safety

By admin, 12 October, 2026

Plan on about 9 h 22 min of driving for the 490-mile (788 km) trip from Cholula to Palizada, before any stops.

U.S. State Department travel advisory: Puebla — Level 2, Exercise Increased Caution; Veracruz — Level 2, Exercise Increased Caution; Tabasco — Level 2, Exercise Increased Caution; Campeche — Level 1, Exercise Normal PrecautionsAdvisory issued May 29, 2026; checked September 29, 2026. Campeche is the Mexican state that contains Palizada. See the full advisory for current details.
Museo Nacional de los Ferrocarriles MexicanosCañón del Río Blanco National ParkOrizaba CathedralHuatuscoLa VentaMuseo de Historia de Tabasco Casa de los AzulejosCholulaPalizada
Route from Cholula to Palizada with the 6 stops listed below (blue dots).
Total distance490 mi (788 km)
Time at the wheel, no stops9 h 22 min
Main roads, in orderMEX-190 → MEX-150D → MEX-145D → MEX-180D → MEX-180 → MEX-186 → MEX-217
Mexican states on the routePuebla, Veracruz, Tabasco, Campeche
Toll roads (as marked in OpenStreetMap)MEX-150D, MEX-145D, MEX-180D
Fuel estimate (car at 25 mpg)about 19.6 gal; actual use varies by vehicle and traffic
Stops listed below6

Driving this route in a car with U.S. plates

Temporary vehicle import permit (TIP)Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora)
Mexican auto insuranceRequired for all vehicles: buy a Mexican policy before you drive

Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.

How the Cholula to Palizada drive plays out

MEX-150D (129 mi) and MEX-180 (59 mi) carry about 38% of the 490 miles. It runs through 4 states: Puebla, Veracruz, Tabasco, Campeche. OpenStreetMap marks tolled sections on MEX-150D, MEX-145D and MEX-180D. Of the 6 stops listed below, 3 are within a mile of the road.

The route from Cholula to Palizada, road by road

RoadRoute miles (from–to)Length, miState
local roads0–11Puebla
MEX-1901–54Puebla
connecting roads5–61Puebla
local roads6–104Puebla
connecting roads10–122Puebla
MEX-150D12–141129Puebla, Veracruz
local roads141–252111Veracruz
MEX-145D252–28331Veracruz
MEX-180D283–30421Veracruz
MEX-180304–32319Veracruz, Tabasco
MEX-180D323–35633Tabasco
MEX-180356–39640Tabasco
local roads396–3993Tabasco
MEX-186399–41920Tabasco
local roads419–47758Tabasco
MEX-217477–48912Tabasco, Campeche
local roads489–4901Campeche
  • Mile 73 of this route: Puebla → Veracruz (state line)
  • Mile 321 of this route: Veracruz → Tabasco (state line)
  • Mile 478 of this route: Tabasco → Campeche (state line)

Stops between Cholula and Palizada

  • Right off the route (under 1 mile): Museo Nacional de los Ferrocarriles Mexicanos (mile 7), Cañón del Río Blanco National Park (mile 86), Museo de Historia de Tabasco Casa de los Azulejos (mile 398)
  • Nature and outdoors: Cañón del Río Blanco National Park (mile 86)
  • Museums and history: Museo Nacional de los Ferrocarriles Mexicanos (mile 7), Orizaba Cathedral (mile 94), Huatusco (mile 134), La Venta (mile 323), Museo de Historia de Tabasco Casa de los Azulejos (mile 398)

Museo Nacional de los Ferrocarriles Mexicanos

Mile 7 · Railway museum · 0.5 mi from the route

In Puebla's historic center, this national railway museum studies, preserves and shares Mexico's railroad heritage through exhibits on the history of the trains.

Cañón del Río Blanco National Park

Mile 86 · National park · 0.4 mi from the route

Veracruz is home to Cañón del Río Blanco National Park, a natural area that the Mexican government has set aside for protection.

Orizaba Cathedral

Mile 94 · Cathedral · 1 mi from the route

The Cathedral of St. Michael the Archangel is the main Catholic church of Orizaba, in the state of Veracruz, and the seat of the Diocese of Orizaba.

Huatusco

Mile 134 · Archaeological site · 2 mi from the route · side trip; actual detour depends on access roads

Above the Atoyac River in Carrillo Puerto, Cuauhtochco has a Mexica-era temple that still keeps original surface finishes. Expect no visitor facilities, and consider hiring a local guide.

La Venta

Mile 323 · Archaeological site · 3 mi from the route · side trip; actual detour depends on access roads

Once an important Olmec city, La Venta sits in Tabasco close to Huimanguillo. Monumental sandstone sculptures found at the foot of its main pyramid are among the 200-plus pieces in the site museum.

Museo de Historia de Tabasco Casa de los Azulejos

Mile 398 · Museum · 0.7 mi from the route

The Museo de Historia de Tabasco, housed in the Casa de los Azulejos, is a history museum in the historic center of Villahermosa, Tabasco.

More drives to Palizada

From Cholula to other places in Mexico

Frequently asked questions

How long is the drive from Cholula to Palizada?

About 9 h 22 min of driving without stops, over 490 miles.

How far is Palizada from Cholula by car?

About 490 miles (788 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.

Do I need a permit to drive my U.S. car from Cholula to Palizada?

Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.

Is it safe to drive from Cholula to Palizada?

The U.S. State Department rates Puebla Level 2: Exercise Increased Caution; Veracruz Level 2: Exercise Increased Caution; Tabasco Level 2: Exercise Increased Caution; Campeche Level 1: Exercise Normal Precautions (advisory issued May 29, 2026). Read the full advisory before you go.

Which highways go from Cholula to Palizada?

In order: MEX-190, MEX-150D, MEX-145D, MEX-180D, MEX-180, MEX-186 and MEX-217. The road-by-road table above shows the route miles for each one.

What are good stops between Cholula and Palizada?

Closest to the road: Museo Nacional de los Ferrocarriles Mexicanos (railway museum, mile 7, 0.5 mi from the route); Cañón del Río Blanco National Park (national park, mile 86, 0.4 mi from the route); Museo de Historia de Tabasco Casa de los Azulejos (museum, mile 398, 0.7 mi from the route). All stops are described above.

How we put this guide together

Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.

Route data © OpenStreetMap contributors.