The Wayro route from Cholula to Guadalupe, Zacatecas is 444 miles (714 km), about 7 h 32 min of driving without stops.
| Distance | 444 mi (714 km) |
|---|---|
| Driving time, no stops | 7 h 32 min |
| Main roads, in order | MEX-150 → MEX-M40D → MEX-57D → MEX-47D → MEX-45D → MEX-45 |
| Mexican states on the route | Puebla (Level 2), Tlaxcala (Level 2), Hidalgo (Level 2), State of Mexico (Level 2), Querétaro (Level 2), Guanajuato (Level 3), Jalisco (Level 3), Aguascalientes (Level 2), Zacatecas (Level 4) |
| Toll roads | MEX-M40D, MEX-57D, MEX-47D, MEX-45D |
| Fuel estimate (car at 25 mpg) | about 17.7 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Driving this route in a car with U.S. plates
| Temporary vehicle import permit (TIP) | Required: this route is outside the zones where U.S.-registered cars can skip the temporary import permit (Baja California, Baja California Sur and part of Sonora) |
|---|---|
| Mexican auto insurance | Required for all vehicles: buy a Mexican policy before you drive |
Sources: U.S. State Department, Mexico travel information (updated August 11, 2026); permits are issued by Banjercito.
What the drive from Cholula to Guadalupe, Zacatecas is like
MEX-45D (162 mi) and MEX-M40D (106 mi) carry about 60% of the 444 miles. MEX-M40D, MEX-57D, MEX-47D, MEX-45D are toll highways (cuota); MEX-150, MEX-45 are free federal roads (libre). It runs through 9 states: Puebla, Tlaxcala, Hidalgo, State of Mexico, Querétaro, Guanajuato, Jalisco, Aguascalientes, Zacatecas. Of the 8 stops listed below, 1 are within a mile of the road.
The route from Cholula to Guadalupe, Zacatecas, road by road
| Road | Route miles (from–to) | Length, mi | State |
|---|---|---|---|
| local roads | 0–1 | 1 | Puebla |
| MEX-150 | 1–9 | 8 | Puebla |
| local roads | 9–21 | 12 | Puebla |
| MEX-M40D | 21–127 | 106 | Puebla, Tlaxcala, Hidalgo, State of Mexico |
| MEX-57D | 127–162 | 35 | Hidalgo, State of Mexico |
| MEX-47D | 162–216 | 54 | Querétaro, Guanajuato |
| MEX-45D | 216–357 | 141 | Guanajuato, Jalisco |
| MEX-45 | 357–386 | 29 | Jalisco, Aguascalientes |
| local roads | 386–390 | 4 | Aguascalientes |
| MEX-45 | 390–418 | 28 | Aguascalientes, Zacatecas |
| MEX-45D | 418–439 | 21 | Zacatecas |
| local roads | 439–444 | 5 | Zacatecas |
- Mile 25 of this route: Puebla → Tlaxcala (state line)
- Mile 48 of this route: Tlaxcala → Hidalgo (state line)
- Mile 56 of this route: Hidalgo → State of Mexico (state line)
- Mile 68 of this route: State of Mexico → Hidalgo (state line)
- Mile 85 of this route: Hidalgo → State of Mexico (state line)
- Mile 99 of this route: State of Mexico → Hidalgo (state line)
- Mile 128 of this route: Hidalgo → State of Mexico (state line)
- Mile 162 of this route: State of Mexico → Querétaro (state line)
- Mile 203 of this route: Querétaro → Guanajuato (state line)
- Mile 312 of this route: Guanajuato → Jalisco (state line)
- Mile 360 of this route: Jalisco → Aguascalientes (state line)
- Mile 414 of this route: Aguascalientes → Zacatecas (state line)
Stops between Cholula and Guadalupe, Zacatecas
- Right off the route (under 1 mile): Aguascalientes Museum (mile 375)
- Nature and outdoors: Parque nacional Xicoténcatl (mile 25), Cerro de las Campanas (mile 204)
- Museums and history: Teotihuacan (mile 67), Aguascalientes Museum (mile 375), Museo de la Insurgencia (mile 395)
Convento de Huejotzingo
Founded by Franciscans in the 16th century, the former convent of San Miguel Arcángel in Huejotzingo shows colonial Plateresque architecture on the western slopes of Popocatépetl and Iztaccíhuatl. UNESCO declared it a World Heritage Site in 1994.
Exconvent of Santa María Magdalena
The former convent of Santa María Magdalena (Exconvento de Santa María Magdalena) is a 17th-century Baroque church built by the Dieguino friars, still in use as a Catholic temple of the Archdiocese of Puebla.
Parque nacional Xicoténcatl
Covering roughly 600 hectares in central Tlaxcala, Xicohténcatl National Park takes in the historic center of Tlaxcala city plus Quiahuixtlán, Ocotelulco and Tepeticpac, which correspond to three of the old Tlaxcalan lordships.
Teotihuacan
Built between the 1st and 7th centuries AD, this UNESCO-listed ancient city lines the Avenue of the Dead, where you can walk between the Pyramid of the Sun, the Pyramid of the Moon and the Temple of the Feathered Serpent.
Atlantean figures
Crowning the main pyramid at the Tula archaeological zone, these basalt sculptures of Toltec warriors stand more than four meters tall in what was once the Toltec capital; the nearby Wall of Snakes shows carved serpents devouring skeletons.
Cerro de las Campanas
Rising within Querétaro City, the Cerro de las Campanas is a hill that is protected as a Mexican national park.
Aguascalientes Museum
Located in the state capital, the Aguascalientes Museum is the city's art museum, set in the city of Aguascalientes, Mexico.
Museo de la Insurgencia
Set in a 17th-century estate, the Museo de la Insurgencia opened in 1964 to tell the story of Mexico's independence movement. One hall shows farm, mining and textile tools from hacienda work; another displays everyday objects from past eras.
When you get to Guadalupe, Zacatecas
Museo Toma de Zacatecas
On the Cerro de la Bufa, this museum explains the military and social story behind the Taking of Zacatecas during the Mexican Revolution, along with glimpses of daily life in the city at the time.
Cathedral Basilica of Zacatecas
Dedicated to the Virgin of the Assumption, the Cathedral of Zacatecas is the main church of the Diocese of Zacatecas.
Teatro Fernando Calderón
Built between 1891 and 1897 to plans by architect George Edward King, Zacatecas' Teatro Calderón honors playwright Fernando Calderón and witnessed violent events during the Toma de Zacatecas.
More drives to Guadalupe, Zacatecas
- Guadalajara to Guadalupe, Zacatecas
- Uruapan to Guadalupe, Zacatecas
- Morelia to Guadalupe, Zacatecas
- Salamanca to Guadalupe, Zacatecas
- Querétaro to Guadalupe, Zacatecas
- San Juan del Río to Guadalupe, Zacatecas
From Cholula to other places in Mexico
- Cholula to Apizaco
- Cholula to Calpulalpan
- Cholula to Otumba
- Cholula to Omitlán
- Cholula to Tepotzotlán
- Cholula to Huasca de Ocampo
Continue Your Adventure
Frequently asked questions
How long is the drive from Cholula to Guadalupe, Zacatecas?
About 7 h 32 min of driving without stops, over 444 miles.
How far is Guadalupe, Zacatecas from Cholula by car?
About 444 miles (714 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Do I need a permit to drive my U.S. car from Cholula to Guadalupe, Zacatecas?
Yes. A temporary vehicle import permit (TIP) is required for a U.S.-registered car on this route, which is outside the zones where it can be skipped. Mexican auto insurance is required for every vehicle.
Is it safe to drive from Cholula to Guadalupe, Zacatecas?
The U.S. State Department rates Puebla Level 2: Exercise Increased Caution; Tlaxcala Level 2: Exercise Increased Caution; Hidalgo Level 2: Exercise Increased Caution; State of Mexico Level 2: Exercise Increased Caution; Querétaro Level 2: Exercise Increased Caution; Guanajuato Level 3: Reconsider Travel; Jalisco Level 3: Reconsider Travel; Aguascalientes Level 2: Exercise Increased Caution; Zacatecas Level 4: Do Not Travel (advisory issued May 29, 2026). Read the full advisory before you go.
What roads does the drive from Cholula to Guadalupe, Zacatecas use?
In order: MEX-150, MEX-M40D, MEX-57D, MEX-47D, MEX-45D and MEX-45. The road-by-road table above shows the route miles and states for each one.
What are good stops between Cholula and Guadalupe, Zacatecas?
Closest to the road: Convento de Huejotzingo (convent, mile 9, 1 mi from the route); Atlantean figures (atlantean figures, mile 116, 1 mi from the route); Aguascalientes Museum (art museum, mile 375, 0.4 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway mile markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route (roughly 2 to 7 miles depending on the type, farther for World Heritage sites): at least one strong stop for each stretch of the drive, then the best-known places nearest the road, with no more than five of one type, up to nine in all. Places that are closed, private or not open to visitors are removed. Place and city descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on September 29, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.