The Wayro route from Berisso to Mercedes, Uruguay is 224 miles (360 km), about 4 h 35 min of driving without stops. You cross from Argentina into Uruguay at about mile 205, at the Gualeguaychú–Fray Bentos bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “Traffic fatalities are high in Uruguay.”
| Total distance | 224 mi (360 km) |
|---|---|
| Driving time, no stops | 4 h 35 min |
| Main roads, in order | 114-05 → RN1 → AV1-N → RN9 → RP6 → RN12 → RN14 → RN136 |
| Border crossing | about mile 205, Argentina → Uruguay (the Gualeguaychú–Fray Bentos bridge) |
| Regions on the route | Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Río Negro, Soriano |
| Fuel estimate (car at 25 mpg) | about 8.9 gal; actual use varies by vehicle and traffic |
| Stops listed below | 8 |
Getting across the Argentina–Uruguay border
The route crosses at about mile 205, at the Gualeguaychú–Fray Bentos bridge, from Entre Ríos into Río Negro. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
What the drive from Berisso to Mercedes is like
RN12 (47 mi) and RN9 (40 mi) carry about 39% of the 224 miles. The first 205 miles are in Argentina; the last 19 are in Uruguay. It runs through 5 regions: Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Río Negro, Soriano. Of the 8 stops listed below, 3 are within a mile of the road.
Road-by-road breakdown: Berisso to Mercedes
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–1 | 1 | Buenos Aires |
| 114-05 | 1–4 | 3 | Buenos Aires |
| connecting roads | 4–7 | 3 | Buenos Aires |
| RN1 | 7–37 | 30 | Buenos Aires, Ciudad de Buenos Aires |
| local roads | 37–40 | 3 | Ciudad de Buenos Aires |
| AV1-N | 40–46 | 6 | Ciudad de Buenos Aires |
| connecting roads | 46–48 | 2 | Ciudad de Buenos Aires |
| RN9 | 48–88 | 40 | Ciudad de Buenos Aires, Buenos Aires |
| RP6 | 88–93 | 5 | Buenos Aires |
| RN12 | 93–140 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 140–176 | 36 | Entre Ríos |
| local roads | 176–183 | 7 | Entre Ríos |
| RN136 | 183–202 | 19 | Entre Ríos |
| connecting roads | 202–205 | 3 | Entre Ríos |
| local roads | 205–224 | 19 | Río Negro, Soriano |
- Mile 33 of this route: Buenos Aires → Ciudad de Buenos Aires (region line)
- Mile 49 of this route: Ciudad de Buenos Aires → Buenos Aires (region line)
- Mile 110 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 205 of this route: Entre Ríos → Río Negro (international border)
- Mile 221 of this route: Río Negro → Soriano (region line)
What to see on the way from Berisso to Mercedes
- Right off the route (under 1 mile): Museo Ferroviario de Tolosa (mile 7), Museo de la Pasión Boquense (mile 36), Santo Domingo Convent (mile 38)
- Nature and outdoors: Parque Natural Municipal Ribera Norte (mile 52)
- Museums and history: Museo Ferroviario de Tolosa (mile 7), Museo de la Pasión Boquense (mile 36), Museum of Foreign Debt (mile 40), Museo Nacional del Hombre (mile 44)
- With kids: The Children's Republic (mile 10)
Museo Ferroviario de Tolosa
Run by the Tolosa branch of the Ferroclub Argentino, created in 1996, the Museo Ferroviario "Ing. Pedro C. Saccaggio" is a railway museum in Tolosa.
The Children's Republic
Spread over 131 acres in La Plata, The Children's Republic is a theme park with 35 scale-model buildings.
Museo de la Pasión Boquense
Football fans can dig into the history and personalities of Club Atlético Boca Juniors at the Museo de la Pasión Boquense, a themed soccer museum devoted to the club.
Santo Domingo Convent
Dating from colonial times, the Santo Domingo Convent in Buenos Aires's Monserrat neighborhood saw fighting during the British invasions of the Río de la Plata.
Museum of Foreign Debt
Inside the University of Buenos Aires Faculty of Economic Sciences, the Museum of Foreign Debt is a public museum showing how foreign debt has shaped Argentina's economic development.
Museo Nacional del Hombre
In the Belgrano district of Buenos Aires, the Museo Nacional del Hombre is a national museum focused on the archaeology of South America's Indigenous peoples.
Parque Natural Municipal Ribera Norte
On the Río de la Plata shore in Acassuso, San Isidro, Ribera Norte is a municipal nature park protecting green space within greater Buenos Aires.
Frigorífico Anglo del Uruguay
The former Anglo meatpacking plant on the Uruguay River at Fray Bentos began shipping frozen meat in 1924, on the site where Liebig exported meat extract and corned beef from 1865. It is part of a UNESCO World Heritage landscape inscribed in 2015.
When you get to Mercedes
Calera Real del Dacá
On the eastern edge of Mercedes beside the Dacá stream, the ruins of the Calera Real lime works date to 1722 and are considered the region's first industrial site; recent works added visitor circuits, lighting and interpretive signs.
Cathedral of Mercedes
Mercedes, Uruguay, centers its Catholic life on the Cathedral of Our Lady of Mercy, which became the seat of the local diocese in 1960.
Alejandro Berro Paleontology Museum
In a 19th-century building in Mercedes' Parque Castillo Mauá, this paleontology museum opened in 1946 around the collection of naturalist Alejandro Berro; a well-preserved glyptodon shell found on a nearby riverbank is a highlight.
More drives to Mercedes
- Salto to Mercedes, Uruguay
- Rivera to Mercedes, Uruguay
- Artigas to Mercedes, Uruguay
- Montevideo to Mercedes, Uruguay
- Melo to Mercedes, Uruguay
- Buenos Aires to Mercedes, Uruguay
More drives from Berisso
- Berisso to Adrogué
- Berisso to Tigre
- Berisso to San Antonio de Areco
- Berisso to Arrecifes
- Berisso to Martínez
- Berisso to Colón, Argentina
Continue Your Adventure
Frequently asked questions
How long is the drive from Berisso to Mercedes, Uruguay?
About 4 h 35 min of driving without stops, over 224 miles.
What is the driving distance from Berisso to Mercedes, Uruguay?
About 224 miles (360 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Berisso to Mercedes drive cross the border?
At about mile 205, from Argentina into Uruguay, at the Gualeguaychú–Fray Bentos bridge.
What do U.S. citizens need to drive from Berisso into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
Is it safe to drive from Berisso to Mercedes, Uruguay?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Berisso to Mercedes use?
In order: 114-05, RN1, AV1-N, RN9, RP6, RN12, RN14 and RN136. The road-by-road table above shows the route miles for each one.
What are good stops between Berisso and Mercedes?
Closest to the road: Museo Ferroviario de Tolosa (railway museum, mile 7, 0.8 mi from the route); Museo de la Pasión Boquense (sports museum, mile 36, 0.6 mi from the route); Santo Domingo Convent (convent, mile 38, 0.3 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.