Plan on about 11 h 9 min of driving for the 514-mile (828 km) trip from Berisso to Melo, Uruguay, before any stops. You cross from Argentina into Uruguay at about mile 243, at the Colón–Paysandú bridge.
Full advisory: Argentina, Uruguay. Advisory issued: Argentina July 10, 2026; Uruguay July 28, 2026; checked October 10, 2026.
On the roads, the State Department says:
- Argentina: “Drivers in Argentina tend to be aggressive, especially in Buenos Aires, and often ignore traffic regulations.”
- Uruguay: “If you are in an accident involving injury, stay in place until a police officer arrives.”
| Distance by road | 514 mi (828 km) |
|---|---|
| Drive time without stops | 11 h 9 min |
| Main roads, in order | 114-05 → RN1 → AV1-N → RN9 → RP6 → RN12 → RN14 → RN135 |
| Border crossing | about mile 243, Argentina → Uruguay (the Colón–Paysandú bridge) |
| Regions on the route | Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Paysandú, Salto, Tacuarembó, Cerro Largo |
| Fuel estimate (car at 25 mpg) | about 20.6 gal; actual use varies by vehicle and traffic |
| Stops listed below | 9 |
Border crossing: what to bring for Uruguay
The route crosses at about mile 243, at the Colón–Paysandú bridge, from Entre Ríos into Paysandú. Plan on two checks on each side: immigration for your passport and customs for the car.
| Entering Uruguay (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. |
|---|---|
| Driving in Uruguay | You can drive on your U.S. license. |
| Entering Argentina (U.S. citizens) | No visa needed for visits of 90 days or less. Passport: must be valid when you enter; leave a blank page for the entry and exit stamps. |
| Driving in Argentina | A valid U.S. license usually works; an International Driving Permit is recommended. |
| Rental car | Cross only if the rental company authorizes it in writing and gives you the papers for the border; ask before you book. |
Sources: U.S. State Department, Uruguay (updated August 13, 2026); U.S. State Department, Argentina (updated July 16, 2026). Checked October 10, 2026; rules change, so confirm before you go.
How the Berisso to Melo drive plays out
RN14 (94 mi) and RN12 (47 mi) carry about 27% of the 514 miles. The first 243 miles are in Argentina; the last 271 are in Uruguay. It runs through 7 regions: Buenos Aires, Ciudad de Buenos Aires, Entre Ríos, Paysandú, Salto, Tacuarembó, Cerro Largo. Of the 9 stops listed below, 7 are within a mile of the road.
Roads you'll take from Berisso to Melo
| Road | Route miles (from–to) | Length, mi | Region |
|---|---|---|---|
| local roads | 0–1 | 1 | Buenos Aires |
| 114-05 | 1–4 | 3 | Buenos Aires |
| connecting roads | 4–7 | 3 | Buenos Aires |
| RN1 | 7–37 | 30 | Buenos Aires, Ciudad de Buenos Aires |
| local roads | 37–40 | 3 | Ciudad de Buenos Aires |
| AV1-N | 40–46 | 6 | Ciudad de Buenos Aires |
| connecting roads | 46–48 | 2 | Ciudad de Buenos Aires |
| RN9 | 48–88 | 40 | Ciudad de Buenos Aires, Buenos Aires |
| RP6 | 88–93 | 5 | Buenos Aires |
| RN12 | 93–140 | 47 | Buenos Aires, Entre Ríos |
| RN14 | 140–234 | 94 | Entre Ríos |
| RN135 | 234–242 | 8 | Entre Ríos |
| local roads | 242–514 | 272 | Entre Ríos, Paysandú, Salto, Tacuarembó, Cerro Largo |
- Mile 33 of this route: Buenos Aires → Ciudad de Buenos Aires (region line)
- Mile 49 of this route: Ciudad de Buenos Aires → Buenos Aires (region line)
- Mile 110 of this route: Buenos Aires → Entre Ríos (region line)
- Mile 243 of this route: Entre Ríos → Paysandú (international border)
- Mile 351 of this route: Paysandú → Salto (region line)
- Mile 357 of this route: Salto → Paysandú (region line)
- Mile 367 of this route: Paysandú → Tacuarembó (region line)
- Mile 474 of this route: Tacuarembó → Cerro Largo (region line)
Stops between Berisso and Melo
- Right off the route (under 1 mile): Museo Ferroviario de Tolosa (mile 7), Anglican Cathedral of St. John the Baptist (mile 39), Torre Monumental (mile 39), El Rosedal De Palermo (mile 43), Temaikèn (mile 71), Museo Carlos Gardel (mile 373), Zoológico Municipal Dr. Mauricio López Lomba (mile 391)
- Nature and outdoors: Buenos Aires Botanical Garden (mile 42), El Rosedal De Palermo (mile 43), Pozo Hondo (mile 371)
- Museums and history: Museo Ferroviario de Tolosa (mile 7), Anglican Cathedral of St. John the Baptist (mile 39), Torre Monumental (mile 39), Museo Carlos Gardel (mile 373)
- With kids: Temaikèn (mile 71), Zoológico Municipal Dr. Mauricio López Lomba (mile 391)
Museo Ferroviario de Tolosa
Run by the Tolosa branch of the Ferroclub Argentino, created in 1996, the Museo Ferroviario "Ing. Pedro C. Saccaggio" is a railway museum in Tolosa.
Anglican Cathedral of St. John the Baptist
Buenos Aires is home to the Anglican Cathedral of St. John the Baptist, the city's Anglican cathedral church.
Torre Monumental
Formerly called Torre de los Ingleses, Torre Monumental is a clock tower in the Retiro area of Buenos Aires, standing in Plaza Fuerza Aérea Argentina.
Buenos Aires Botanical Garden
In the Palermo neighborhood of Buenos Aires, the Buenos Aires Botanical Garden fills a triangular plot bounded by Santa Fe Avenue, Las Heras Avenue and República Árabe Siria Street.
El Rosedal De Palermo
Part of Parque Tres de Febrero in Palermo, the Rosedal covers 3.4 hectares with about 18,000 rose bushes, busts of 26 poets and writers, a Greek-style bridge and an Andalusian patio.
Temaikèn
Temaikèn is a zoo in Belén de Escobar, outside Buenos Aires, and the only zoo in Argentina accredited by the Association of Zoos and Aquariums.
Pozo Hondo
Pozo Hondo is a waterfall in Uruguay's Tacuarembó department, located between the towns of Valle Edén and Tambores.
Museo Carlos Gardel
Dedicated to the life and work of Carlos Gardel, this museum is in Valle Edén, Tacuarembó department, 21 kilometers from the city of Tacuarembó.
Zoológico Municipal Dr. Mauricio López Lomba
Reachable from Route 5 at kilometer 390, the Mauricio López Lomba reserve is a wildlife reserve in the city of Tacuarembó, Uruguay.
Arriving in Melo
Cathedral of Melo
The Cathedral of Our Lady of the Pillar and St. Raphael is the main Roman Catholic church in the city of Melo, Uruguay.
Regional History Museum of Melo
Founded on June 27, 1976, Melo's municipal history museum displays archaeological pieces and historical items from the region and hosts temporary exhibitions and talks.
More drives to Melo
- Montevideo to Melo
- Paysandú to Melo
- Buenos Aires to Melo, Uruguay
- Rosario, Argentina to Melo, Uruguay
- Santa Fe to Melo, Uruguay
- Paraná to Melo, Uruguay
More drives from Berisso
- Berisso to Adrogué
- Berisso to Tigre
- Berisso to San Antonio de Areco
- Berisso to Arrecifes
- Berisso to Martínez
- Berisso to Colón, Argentina
Continue Your Adventure
Frequently asked questions
How long does it take to drive from Berisso to Melo, Uruguay?
About 11 h 9 min of driving without stops, over 514 miles.
How far is Melo, Uruguay from Berisso by car?
About 514 miles (828 km) on the Wayro route. Other map services may show a few miles more or less, depending on where they start and end in each city.
Where does the Berisso to Melo drive cross the border?
At about mile 243, from Argentina into Uruguay, at the Colón–Paysandú bridge.
What do U.S. citizens need to drive from Berisso into Uruguay?
No visa needed for visits of 90 days or less. Passport: must be valid for 6 months beyond your arrival date. You can drive on your U.S. license. (U.S. State Department, updated August 13, 2026.)
Is it safe to drive from Berisso to Melo, Uruguay?
The U.S. State Department rates Argentina Level 1: Exercise Normal Precautions; Uruguay Level 2: Exercise Increased Caution. Read the full advisory before you go.
What roads does the drive from Berisso to Melo use?
In order: 114-05, RN1, AV1-N, RN9, RP6, RN12, RN14 and RN135. The road-by-road table above shows the route miles for each one.
What are good stops between Berisso and Melo?
Closest to the road: Anglican Cathedral of St. John the Baptist (cathedral, mile 39, 0.2 mi from the route); Torre Monumental (monument, mile 39, 0.3 mi from the route); Zoológico Municipal Dr. Mauricio López Lomba (zoo, mile 391, 0.1 mi from the route). All stops are described above.
How we put this guide together
Wayro calculates the route from OpenStreetMap road data; mile numbers are positions along this route, not highway markers, and "from the route" distances are straight-line, so the real detour depends on access roads. Stops are chosen from parks, natural sites, museums, historic sites and attractions close to the route: at least one strong stop for each stretch of the drive, then the best-known places nearest the road, up to nine in all. Places that are closed, private or not open to visitors are removed. Place descriptions are written by the Wayro team from official park, museum, tourism and government websites and other published sources. Safety levels and entry rules were checked against the U.S. Department of State on October 10, 2026. Conditions change, so check the linked sources before you travel.
Route data © OpenStreetMap contributors.